Search for dissertations about: "synthesis of triazole derivatives"

Found 3 swedish dissertations containing the words synthesis of triazole derivatives.

  1. 1. Synthesis of sulfur and selenium heterocycles, including derivatives of imidazopyridine and benzimidazole

    Author : Malin Björk; Spiros Grivas; Christopher A. Ramsden; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Aminoimidazoazaarenes; thienomethyleneimidazolinones; imidazo[4; 5b]pyridines; Friedländer; imidazo[4; 5-e]-2; 1; 3-benzoselenadiazoles; 2-aminobenzimidazoles. palladium catalyzed coupling reactions.;

    Abstract : The chemistry developed in this thesis can be divided into two parts. The first part, which is the major part of the thesis, contains syntheses towards analogues to mutagenic heterocyclic amines found in e.g. meat fried at high temperatures. READ MORE

  2. 2. Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors

    Author : Mariell Pettersson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interactionProtein-protein interaction; MDM2 p53 interaction; MDM2 inhibitors; α- helix mimetics; β-hairpin; 2; 5-diketopiperazine; spiro-2; 5-diketopiperazine; purine; 8- triazolyl purine; solution conformational analysis; NAMFIS; fluorescence;

    Abstract : Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its involvement in DNA repair, induction of cell cycle arrest and cellular apoptosis. READ MORE

  3. 3. Valorisation of Renewable Building Blocks via Transition Metal Catalysis – Glycerol- and Amino Acid Derived Compounds in Hydrogen Borrowing and RuAAC Reactions

    Author : Anna Said Stålsmeden; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amination; alkylation; RuAAC; 1 3-propanediol; renewable precursors; hydrogen borrowing; 1 2 3-triazole; solketal; glycerol; amino acid-derived azide;

    Abstract : To a large extent, organic building blocks are today obtained from petroleum-based products. From an environmental point of view, biomass-derived compounds are more sustainable alternatives to such oil-derived molecules. The 12 principles of green chemistry describe how chemical processes can be improved in terms of sustainability. READ MORE