Search for dissertations about: "synthesised design model"
Showing result 1 - 5 of 16 swedish dissertations containing the words synthesised design model.
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1. A Novel Submarine Design Method - Based on technical, economical and operational factors of influence
Abstract : The thesis work, with the openly published journal and conference papers, is motivated by theambition to interact over time with the scientific community in the development of a novelcoherent submarine design method to regain momentum in Swedish submarine computeraided Simulation Based Design (SBD). The work was initially stimulated by an earlyobservation in our submarine engineering community, that the existing knowledge of navalarchitecture and systems theory including cost prediction and operational analysis was notcoherently utilised for the design of Naval Integrated Complex System (NICS), hence theneed for a coherent approach. READ MORE
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2. New alternatives to combat Listeria monocytogenes and Chlamydia trachomatis : Design, synthesis, and evaluation of substituted ring-fused 2-pyridones as anti-virulent agents
Abstract : Antibiotic resistance has become a global health burden with the number of resistant bacteria continuously increasing. Antibiotic drugs act by being either bactericidal (killing bacteria) or bacteriostatic (inhibiting growth of bacteria). However, these modes of action increase the selective pressure on the bacteria. READ MORE
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3. Design, Synthesis and Evaluation of Catalytic Chalcogenide Antioxidants
Abstract : This thesis describes the design, synthesis and evaluation of novel chalcogenide antioxidants.A computational model for the prediction of antioxidant properties of chalcogen-containing antioxidants has been developed. READ MORE
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4. The MHC-glycopeptide-T cell interaction in collagen induced arthritis : a study using glycopeptides, isosteres and statistical molecular design in a mouse model for rheumatoid arthritis
Abstract : Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1% of the population in the western world. It is characterised by a tissue specific attack of cartilage in peripheral joints. Collagen induced arthritis (CIA) is one of the most commonly used animal models for (RA), with similar symptoms and histopathology. READ MORE
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5. Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors
Abstract : Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes present in all living organisms, their catalytic activity is involved in the translation of the genetic code into functional proteins and they are potential targets for anti-infective agents. The first step in the biosynthetic pathway catalysed by aaRSs consists of activation of the corresponding amino acid by the reaction with ATP to form an aminoacyl-adenylate (aa-AMP), the key intermediate in the biosynthesis of proteins. READ MORE