Search for dissertations about: "synthetic compound"

Showing result 1 - 5 of 92 swedish dissertations containing the words synthetic compound.

2. 1. Galiellalactone Synthetic Studies

   Author : Zilma Escobar; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; natural product; galiellalactone; prostate cancer; STAT3.;

   Abstract : In search for remedies and treatments, science has recurred to Mother Nature. This is where galiellalactone was found, a fungal metabolite isolated from Galiella rufa in 1990. Since then chemists and biologists have been studying its properties and found it to be a potential candidate against castration-resistance prostate cancer (CRPC). READ MORE

4. 2. Synthetic studies of heterocyclic natural products

   Author : Jeffrey J Mason; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Heterocycles; alkaloids; natural products; luotonin A; cephalandole A; cephalandole B; benzoxazinone; tryptanthrin; ophiuroidine; pyrroloquinazolinone; isatin; Prey demethylation; pyridinium hydrochloride; demethylation; microwave synthesis;

   Abstract : The methods that were developed for the synthesis of the heterocyclic natural products luotonin A, ophiuroidine, cephalandole B, and the indol-3-yl-benzoxazinones of cephalandole A are described in this thesis. The reoccurrence of the 4(3H)-quinazolinone structure is a common theme throughout these studies, and an overview of some quinazoline chemistry is introduced in the first chapter. READ MORE

5. 3. The development of synthetic gene delivery systems

   Author : Lars J Brandén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : gene transfer; synthetic vector; gene therapy; Bioplex; PNA; NLS;

   Abstract : This thesis describes a new platform technology. The technique is referred to as Bioplex (biological complex) in analogy with the nomenclature for other transfection reagents, since we attach biological functions to a nucleic acid complex via sequence-specific hybridisation. READ MORE

6. 4. Synthetic [FeFe] Hydrogenase Active Site Model Complexes

   Author : Lennart Schwartz; Sascha Ott; Marcetta Y. Darensbourg; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; hydrogenase mimic; proton reduction; bioinorganic chemistry; diiron hexacarbonyl complexes; artifical photosynthesis; hydrogen; Organic chemistry; Organisk kemi;

   Abstract : [FeFe]-Hydrogenases (H2ases) are metalloenzymes that can catalyze the reversible reduction of protons to molecular hydrogen as part of the metabolism of certain cyanobacteria and green algae. Due to the low availability of the enzyme, synthetic complexes that mimic the natural active site in structure, function and activity are highly sought after. READ MORE

7. 5. The discovery of antiviral compounds targeting adenovirus and herpes simplex virus : assessment of synthetic compounds and natural products

   Author : Mårten Strand; Göran Wadell; Mikael Elofsson; Ya-Fang Mei; Lieve Naesens; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virology; antiviral; adenovirus; herpes simplex virus; small molecule; inhibitor; hsv; drug discovery; medicinsk virologi; Medical Virology; datorlingvistik; computational linguistics; mikrobiologi; Microbiology;

   Abstract : There is a need for new antiviral drugs. Especially for the treatment of adenovirus infections, since no approved anti-adenoviral drugs are available. Adenovirus infections in healthy persons are most often associated with respiratory disease, diarrhea and infections of the eye. These infections can be severe, but are most often self-limiting. READ MORE