Search for dissertations about: "synthetic lethality"

Showing result 1 - 5 of 7 swedish dissertations containing the words synthetic lethality.

  2. 1. Factors modulating tRNA biogenesis and function in Saccharomyces cerevisiae

    Author : Fu Xu; Anders Byström; Marcus J. O. Johansson; Raffael Schaffrath; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Translation; tRNA biogenesis; suppressor tRNA; Elongator complex; wobble uridine modifications; SUP4; YPK9; SSD1; serine tRNA; synthetic lethality; yeast; biology; biologi; molekylärbiologi; Molecular Biology; Genetics; genetik;

    Abstract : Transfer RNA (tRNA) genes are transcribed by RNA polymerase III as precursors that undergo multiple processing steps to form mature tRNAs. These steps include processing of the 5’ leader and 3’ trailer sequences, addition of a 3’ CCA tail, removal of introns, and formation of modified nucleosides. READ MORE

  4. 2. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy

    Author : Simon Hultmark; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acute myeloid leukaemia; Hematologi; stem cells; differentiation induction; leukaemia; treatment; small molecule drugs; PKC; FLT3; shRNA; small molecule inhibitor; Small Molecule Libraries; MEK ERK pathway; natural product; co-culture; drug screening; combination therapy;

    Abstract : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. READ MORE

  5. 3. Inhibition of crucial oncogenes by pharmacologically activated p53

    Author : Yao Shi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor suppressor p53 is a transcriptional factor which is frequently inactivated in cancer, either by point mutations or by its negative regulators, such as Mdm2 and MdmX. Reactivation of p53 by small molecules is a promising strategy to treat cancer. READ MORE

  6. 4. Heparan sulfate dependent cell signaling and associated pathophysiology : Implications in tumorigenesis and embryogenesis

    Author : Tahira Batool; Jin-Ping Li; Aristidis Moustakas; Liliana Schaefer; Ingvar Ferby; Michael Welsh; Anders Malmström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparanase; Glucuronyl-C5 epimerase; Heparan Sulfate; Heparin; Lung Cancer; Cancer cell Singling; TGF-Beta; BMP; VEGF; Notch Signaling; Tumor growth; Metastasis; embryonic development; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Heparan sulfate proteoglycans (HSPGs) consist of a protein core to which several linear, negatively charged heparan sulfate (HS) chains are covalently attached. HSPGs are expressed on the cell surface and in the extra-cellular matrix (ECM) where they have diverse biological functions, for example co-receptor functions. READ MORE

  7. 5. New modifiers of insulin signalling identified by interaction screens with ASNA-1 in C. elegans

    Author : Balasubramanian Natarajan; Peter Naredi; Richard Padgett; Umeå universitet; []
    Keywords : Insulin; C. elegans; ASNA1; Cisplatin; GRP94; unfolded protein response; SMN1; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : Background: Insulin is a hormone released by the pancreatic beta cells in response to elevated levels of nutrients in the blood. Insulin triggers the uptake of glucose, fatty acids and amino acids into the liver, adipose tissue and muscles. READ MORE