Search for dissertations about: "synthetic method development"
Showing result 1 - 5 of 155 swedish dissertations containing the words synthetic method development.
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1. Transition metal-catalyzed allylic and vinylic functionalization : Method development and mechanistic investigations
Abstract : The use of small molecule building blocks in, for example, pharmaceutical research and new material development, creates a need for new and improved organic synthesis methods. The use of transition metals as mediators and catalysts opens up new reaction pathways that have made the synthesis of completely new compounds possible as well as greatly improved the synthetic routes to known compounds. READ MORE
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2. Lanthanide-mediated C-F Bond Activation Method Development and Mechanistic Investigation
Abstract : The use of transition-metals and main-group Lewis acids has proven to be an outstanding source for activation and subsequent functionalization of fluorinated compounds. However, the first is mainly limited to C(sp2)–F bonds which partially are activated by an adjacent heteroatom, and the latter is limited to simple C(sp3)–F bonds due to particularly strong Lewis acid character. READ MORE
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3. A Chemical Approach Toward the Therapeutic Optimization of Cytotoxic Bioconjugates
Abstract : The delivery of cytotoxicity to specific cells was recognized to be the key to the effective, chemical treatment of infectious and neoplastic diseases well over a century ago. In the context of oncology, the primary therapeutic challenge is the distinction between healthy and pathological cells despite their pronounced pheno- and genotypic similarity. READ MORE
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4. Metal release from powder particles in synthetic biological media
Abstract : Humans are exposed to metals and metal-containing materials daily, either conscious, e.g. using metal tools or objects, or unconscious, e.g. READ MORE
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5. Diaryliodonium Salts : Development of Synthetic Methodologies and α-Arylation of Enolates
Abstract : This thesis describes novel reaction protocols for the synthesis of diaryliodonium salts and also provides an insight to the mechanism of α-arylation of carbonyl compounds with diaryliodonium salts. The first chapter gives a general introduction to the field of hypervalent iodine chemistry, mainly focusing on recent developments and applications of diaryliodonium salts. READ MORE