Search for dissertations about: "systemic activity"

Showing result 1 - 5 of 369 swedish dissertations containing the words systemic activity.

2. 1. Systemic sclerosis : vascular, pulmonary and immunological aspects

   Author : Grethe Neumann Andersen; Solbritt Rantapää Dahlqvist; Lucia Mincheva-Nilsson; Sören Jacobsen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; interstitial lung disease; MMP-9; Th1 Th2; transcription factors; NO; iNOS; E-selectin; endothelium-dependent dilation; endothelium-independent dilation.; Rheumatology; Reumatologi;

   Abstract : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. READ MORE

4. 2. Studies on the deposition, bioavailability and systemic activity of glucocorticoids in man

   Author : Lars Thorsson; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; systemic activity; glucocorticosteroids; lung deposition; systemic availability; inhalation; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Abstract : The local deposition, pharmacokinetics, and systemic activity of inhaled and intranasal glucocorticosteroids in different formulations and devices(ICSs) has been investigated. After nasal administration of the ICS budesonide (Bud), the systemic availability (F) was found to be significantly higher from an aqueous pump spray and from the powder inhaler Turbuhaler, than from a pressurized metered dose inhaler (pMDI), and the uptake process was slower and less complete with the pMDI formulation. READ MORE

5. 3. The Activity Diamond - Modeling an Enhanced Accessibility

   Author : Per-Olof Hedvall; Bodil Jönsson; Victor Kaptelinin; Certec - Rehabiliteringsteknik och Design; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Activity Diamond; Cultural-historical Activity Theory; Disability; Epiaccessibility; Accessibility; Lived Accessibility; Design; ICF; Social model; Activity Diamond; Cultural-historical Activity Theory; Disability; Epiaccessibility; Accessibility; Lived Accessibility; Design; ICF; Social model;

   Abstract : The purpose of the research presented in this thesis is to enhance the field of accessibility to include a multitude of perspectives. Based on cultural-historical activity theory (CHAT), it analyzes how human, artifactual and natural factors impact an individual’s possibilities to act in concrete situations that are part of a systemic whole. READ MORE

6. 4. Representing and Reasoning about Complex Human Activities - an Activity-Centric Argumentation-Based Approach

   Author : Esteban Guerrero Rosero; Helena Lindgren; Juan Carlos Nieves; Chris Reed; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Complex activity; Argumentation Theory; Activity Theory; Logic programming; Knowledge representation; Common-sense reasoning; Artificial Intelligence; business data processing; administrativ databehandling;

   Abstract : The aim of this thesis is to develop theories and formal methods to endow a computing machinery with capabilities to identify, represent, reason and evaluate complex activities that are directed by an individual’s needs, goals, motives, preferences and environment, information which can be inconsistent and incomplete.Current methods for formalising and reasoning about human activity are typically limited to basic actions, e. READ MORE

7. 5. Non-symmetrical pregnane cyclic 16a, 17a-acetals and their C(22) epimers as anti-inflammatory agents : synthesis, structure and topical/systemic activity relationships

   Author : Arne Thalén; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Abstract : .... READ MORE