Search for dissertations about: "systems integration and association"

Showing result 1 - 5 of 24 swedish dissertations containing the words systems integration and association.

2. 1. Governance of innovation - deploying an architectural framework for innovation of technological systems for energy, security and defence

   Author : Bengt A Mölleryd; Per Lundqvist; Gunnar Hult; Per Morten Schiefloe; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Systemic innovation; disruptive innovation; technology innovation; innovation deployment; platform-based ecosystems; governance; innovation life cycle; systems integration and association; systems of systems; energy; security; security of supply; defence; evolutionary development; holistic engineering; systems engineering standards; protocols and methods; enterprise architectures and frameworks; Energy Technology; Energiteknik;

   Abstract : Governance of innovation – deploying an architectural framework for innovation of technological systems for energy, security and defence Innovation has a great deal of attraction but is associated with serious uncertainties and downsides. It is potentially beneficial for growth, sector and industrial development and competitiveness. READ MORE

4. 2. Functional association networks for disease gene prediction

   Author : Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Abstract : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. READ MORE

5. 3. Inference of functional association networks and gene orthology

   Author : Thomas Schmitt; Erik L. L. Sonnhammer; Søren Brunak; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; orthology; InParanoid; FunCoup; systems biology; biological networks; network inference; functional coupling; functional association; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Abstract : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. READ MORE

6. 4. Metabolic Modeling of the Gut Microbiome-Host Interactions and Meta’omics Integration

   Author : Saeed Shoaie; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; meta’omics; complexity; obesity; network topology; Gut microbiome; genome-scale metabolic model; gene richness; CASINO; systems biology; flux balance analysis; diabetes;

   Abstract : A large number of microbes with different strain types occupy the human gut. These gut inhabitant microbes have key roles in decomposition of indigestible dietary macronutrients before they are metabolised by the host. READ MORE

7. 5. Global functional association network inference and crosstalk analysis for pathway annotation

   Author : Christoph Ogris; Erik Sonnhammer; Alfonso Valencia; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; biological networks; genome wide functional association networks; global gene association networks; gene networks; protein networks; functional association; functional coupling; network biology pathway analysis; pathway annotation; pathway enrichment; network-based enrichment; enrichment; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Abstract : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. READ MORE