Search for dissertations about: "tRNA biogenesis"

Showing result 1 - 5 of 6 swedish dissertations containing the words tRNA biogenesis.

2. 1. Factors modulating tRNA biogenesis and function in Saccharomyces cerevisiae

   Author : Fu Xu; Anders Byström; Marcus J. O. Johansson; Raffael Schaffrath; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Translation; tRNA biogenesis; suppressor tRNA; Elongator complex; wobble uridine modifications; SUP4; YPK9; SSD1; serine tRNA; synthetic lethality; yeast; biology; biologi; molekylärbiologi; Molecular Biology; Genetics; genetik;

   Abstract : Transfer RNA (tRNA) genes are transcribed by RNA polymerase III as precursors that undergo multiple processing steps to form mature tRNAs. These steps include processing of the 5’ leader and 3’ trailer sequences, addition of a 3’ CCA tail, removal of introns, and formation of modified nucleosides. READ MORE

4. 2. Structural and functional basis of mitochondrial tRNA processing

   Author : Sagar Sridhara; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) structure and function requires more than 1000 proteins generated from the nuclear DNA (nDNA) expression and 13 protein subunits generated from the mitochondrial DNA (mtDNA) expression. READ MORE

5. 3. The Kluyveromyces lactis killer toxin is a transfer RNA endonuclease

   Author : Jian Lu; Anders Byström; Leif Kirsebom; Umeå universitet; []
   Keywords : Molecular biology; K. lactis γ-toxin; tRNA endonuclease; modified nucleosides; 5-methoxycarbonylmethyl-2-thiouridine; 5-methylaminomethyl-2-thiouridine; anticodon stem loop; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : Killer strains of the yeast Kluyveromyces lactis secrete a heterotrimeric protein toxin (zymocin) to inhibit the growth of sensitive yeasts. The cytotoxicity of zymocin resides in the γ subunit (γ-toxin), however the mechanism of cytotoxicity caused by γ-toxin was previously unknown. READ MORE

6. 4. Post-transcriptional control of stem and cancer cell fate. New roles for an old RNA modification

   Author : Nicola Guzzi; Avdelningen för molekylär hematologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA modifications; pseudouridine; translational control; Stem cells; tRNA-derived fragments; MDS;

   Abstract : Recent advances in high-throughput sequencing technologies uncovered widespread RNA modifications on coding and non-coding RNAs collectively refer to as the epitranscriptome. However, we are only now starting to appreciate the impact of the epitranscriptome in regulating cell biology. READ MORE

7. 5. All Roads Lead to the Non-Coding RNome : Evolution of Multicellularity and Host Response to Bacterial Infection

   Author : Jonas Kjellin; Fredrik Söderbom; Jonathan Chubb; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ncRNA; Dictyostelia; miRNA; Class I RNA; host-pathogen interaction; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Abstract : The ability to control gene expression is fundamental for all living organisms. Therefore, a large variety of regulatory mechanisms exist in each cell which are essential for e.g. developmental processes and to quickly adapt to different cellular stresses such as infection. READ MORE