Search for dissertations about: "tacrine"

Showing result 1 - 5 of 6 swedish dissertations containing the word tacrine.

2. 1. Advanced Mass Spectrometry Imaging in Neuropharmacology

   Author : Theodosia Vallianatou; Per E. Andrén; Anna Nilsson; Mohammadreza Shariatgorji; Maria Karlgren; Irena Loryan; Nathalie Agar; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; neuropharmacology; blood brain barrier; drug-drug interactions; aging; tacrine;

   Abstract : Mass spectrometry imaging (MSI) has emerged as a valuable approach for mapping multiple molecular species in sections of diverse tissues. It enables simultaneous detection of numerous compounds (from neurotransmitters to small proteins) in the brain at relatively high lateral resolution (>5 μm) on a routine basis. READ MORE

4. 2. Cholinesterase inhibitors in Alzheimer's disease : an experimental study on mechanisms of interatcion with muscarinic and nicotinic receptors and neuroprotection

   Author : Anne-Lie Svensson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Alzheimer s disease Cholinesterase inhibitors Muscarinic receptors Nicotinic receptors Acetylcholine release Neuroprotection B-amyloid apolipoprotein E;

   Abstract : The overall aim of this thesis was to investigate the mechanisms beyond the interaction of cholinesterase inhibitors (ChEIs) with the cholinergic system in brain, with emphasis on their regulatory and mechanistic effects on subtypes of muscarinic and nicotinic receptors and neuroprotective properties. To investigate muscarinic receptor subtypes in frontal cortices of AD brains, the muscarinic antagonists pirenzepine, AF-DX 116, HHSiD, p-F-HHSiD and himbacine were used in receptor binding assays. READ MORE

5. 3. Long-term treatment response, predictors and biochemical markers in Alzheimer’s disease

   Author : Åsa Wallin; Klinisk minnesforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; treatment response; cholinesterase inhibitor; CSF-biomarkers; pre-treatment progression; predictors; Alzheimer’s disease;

   Abstract : Alzheimer’s disease (AD) is clinically characterised by an insidious onset with progressive symptoms of memory impairment, dysphasia, dyspraxia, dygnosia and visuospatial difficulties. Degeneration of neurons in specific regions of the brain, formation of senile plaques and neurofibrillary changes are some of the neuropathological features of the disease. READ MORE

6. 4. Early diagnosis of Alzheimer's disease : focus on quantitative EEG in relation to genetic, biochemical and neuroimaging markers

   Author : Vesna Jelic; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The main aims of this thesis were to explore whether quantitative EEG (qEEG) variables could be considered as positive markers of Alzheimer's disease (AD) and sensitive indices of disease progression and treatment effects, as well as to determine their relation to currently existing genetic, biochemical and neuroimaging markers. The main findings of seven subsequent studies are summarized as follows: 1) Combined alpha and theta relative power and temporo-parietal alpha band coherence were the best combination of qEEG variables for the discrimination of mild to moderate AD patients and healthy controls, giving 89% overall correct classification accuracy. READ MORE

7. 5. Functional features of human cytochrome P450 1A2 : with special focus on caffeine and melatonin metabolism

   Author : Anna Nordmark; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Drug metabolism; CYP1A2; caffeine; melatonin; liver slices; in vitro methods;

   Abstract : CYP1A2 is one of the major cytochrome P450 enzymes in the liver and metabolises drugs such as caffeine, clozapine, tacrine, and theophylline. CYP1A2 also has a role in chemical carcinogenesis due to its activation of procarcinogens, such as heterocyclic amines and arylamines. Caffeine is extensively used to assess CYP1A2 activity. READ MORE