Search for dissertations about: "tamoxifen resistance"
Showing result 1 - 5 of 32 swedish dissertations containing the words tamoxifen resistance.
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1. Studies of tamoxifen resistance in breast cancer
Abstract : Oestrogen is one of the most important hormonal regulators and is known to play a key role in the development and growth of breast cancer. The majority of tumours have a hormone dependent growth, and this is indicated by the presence of oestrogen receptors (ERs). READ MORE
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2. Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance
Abstract : Breast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. READ MORE
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3. Predictive markers for tamoxifen response in primary breast cancer
Abstract : It is well-known that a majority of breast cancers are hormone-dependent, making endocrine therapy an important adjuvant treatment after surgery. Susceptibility to endocrine treatment is determined by the presence of estrogen receptors (ER) and progesterone receptors (PR) in the tumors. READ MORE
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4. Erythropoietin receptor in growth control and anti-estrogen resistance of estrogen receptor positive breast cancer
Abstract : The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Therefore, recombinant human EPO (rhEPO) is used to treat anemia in cancer patients, but some studies have reported that rhEPO treatment might promote tumor progression. Additionally, EPOR expression has been detected in various cancer forms. READ MORE
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5. Predicting Prognosis and Tamoxifen Response in Breast Cancer. With a special focus on contralateral breast cancer
Abstract : One of the great challenges in breast cancer treatment today is to customize adjuvant treatment to each patient’s individual needs. To do this it is necessary to learn more about the prognostic and treatment predictive factors that determine the risk of relapse and response to a certain mode of treatment. READ MORE