Search for dissertations about: "tandem duplication"
Showing result 1 - 5 of 14 swedish dissertations containing the words tandem duplication.
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1. Variation in length of proteins by repeats and disorder regions
Abstract : Protein-coding genes evolve together with their genome and acquire changes, some of which affect the length of their protein products. This explains why equivalent proteins from different species can exhibit length differences. READ MORE
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2. Molecular and Clinical Characterization of Syndromes Associated With Intellectual Disability
Abstract : Intellectual disability (ID) affects approximately 1-3% of the population and is defined as having an IQ below 70 as well as a significant limitation in adaptive behavior.The implementation of chromosomal microarrays (CMA) into the field of clinical genetics has revolutionized the ability to find genetic aberrations responsible for different genetic disorders. READ MORE
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3. Creation of new proteins - domain rearrangements and tandem duplications
Abstract : Proteins are modular entities with domains as their building blocks. The domains are recurrent protein fragments with a distinct structure, function and evolutionary history. During evolution, proteins with new functions have been invented through rearrangements as well as differentiation of domains. READ MORE
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4. FLT3 receptor in normal and malignant hematopoiesis
Abstract : All hematopoietic cells originate from hematopoietic stem cells (HSCs) residing in the bone marrow (BM). The classical model of hematopoietic lineage commitment, that has been the prevailing model for hematopoiesis, proposes that the first lineage commitment step of HSCs and progenitors results in a strict separation of myelopoiesis and lymphopoiesis. READ MORE
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5. The relationship between orthology, protein domain architecture and protein function
Abstract : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. READ MORE