Search for dissertations about: "target receptor of cancer"

Showing result 1 - 5 of 208 swedish dissertations containing the words target receptor of cancer.

2. 1. Estrogen receptor alpha and beta in breast cancer - gene expression profiles and clinical implications

   Author : Sofia Gruvberger; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; oncology; cancerology; Cytologi; onkologi; cancer; Cytology; artificial neural networks; gene expression profiling; microarray; tamoxifen; adjuvant endocrine therapy; ER; estrogen receptor beta; Breast cancer; estrogen receptor alpha; Clinical biology;

   Abstract : Breast cancer is the most common malignancy in women in the Western world with about 10% of women developing breast cancer during their lifetime, of which one third will eventually succumb to the metastatic form of the disease. Breast cancer arises from the epithelial cells of the breast mammary gland, but the mechanisms involved in tumor initiation, progression, and metastasis are still not fully understood. READ MORE

4. 2. The role of phosphatidylinositol 4-phosphate 5-kinase type І alpha (PIP5K1α) and utility of its inhibitor for targeting metastatic cancer

   Author : Martuza Sarwar; Malmö Experimentell cancerforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate Cancer; Breast cancer; Cancer therapy; PIP5K1A; PI3K AKT signal pathway; Kinase inhibitors;

   Abstract : Prostate cancer (PCa) is the most common cause of cancer-related death in men after lung cancer. Annually, more than 9000 new cases are diagnosed in Sweden and 2500 of them die each year. Metastatic prostate cancer can be treated with castration. READ MORE

5. 3. Role of ß-catenin and Leukotriene in Colon Cancer Progression

   Author : Tavga Salim; Malmö Cellpatologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; β-catenin; E-cadherin; GSK-3β; inflammation; colorectal cancer;

   Abstract : Abstract Colorectal cancer is the third most common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of colon cancer is inflammatory bowel disease. READ MORE

6. 4. Inhibition of PDGF receptor signaling in tumor stroma : Effects on interstitial hypertension, drug uptake and therapeutic response

   Author : Kristian Pietras; Sven Påhlman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; PDGF; tumor; stroma; tyrosine kinase inhibitor; combination therapy; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

   Abstract : The role of platelet-derived growth factor (PDGF) in malignancies involves both autocrine and paracrine stimulation of cells within the tumor. The interstitial fluid pressure (IFP) is one of the forces that govern the transvascular flow of fluids. READ MORE

7. 5. Cancer Immunotherapy : Evolving Oncolytic viruses and CAR T-cells

   Author : Mohanraj Ramachandran; Magnus Essand; Di Yu; Justyna Leja-Jarblad; Richard Vile; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncolytic virus; Adenovirus; Semliki Forest virus; Cancer immunology; Chimeric antigen receptor T-cells; Immunologi; Immunology; Oncology; Onkologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : In the last decade cancer immunotherapy has taken huge strides forward from bench to bedside and being approved as drugs. Cancer immunotherapy harnesses the power of patient’s own immune system to fight cancer. READ MORE