Search for dissertations about: "targeting"

Showing result 11 - 15 of 1710 swedish dissertations containing the word targeting.

  2. 11. Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy

    Author : Susanna Myhre; Göteborgs universitet; []
    Keywords : Adenovirus; gene therapy; vector; re-targeting; de-targeting; fiber; pIX; affibody molecule; single chain antibody;

    Abstract : Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack of suitable vectors. READ MORE

  4. 12. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects

    Author : Carmine Pasquale Cerrato; Ülo Langel; Lena Mäler; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptide; mitochondrial targeting; ROS reduction; mitochondrial membrane potential; antioxidant activity; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. READ MORE

  5. 13. Targeting and function of CAH1 : Characterization of a novel protein pathway to the plant cell chloroplast

    Author : Stefan Burén; Göran Samuelsson; Muriel Bardor; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Arabidopsis; chloroplast; endomembrane system; CAH1; protein targeting; N-glycosylation; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The chloroplast is the organelle within a plant cell where photosynthesis takes place. This organelle originates from a cyanobacterium that was engulfed by a eukaryotic cell. READ MORE

  6. 14. Cell-Penetrating Peptides for Mitochondrial Targeting

    Author : Carmine Pasquale Cerrato; Ülo Langel; Shana O. Kelley; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial targeting; cell-penetrating peptides; antioxidant activity; scavenging ability; oligonucleotide delivery; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Mitochondria have simply been known as the cell’s powerhouse for a long time, with its vital function of producing ATP. However, substantially more attention was directed towards these organelles once they were recognized to perform several essential functions having an impact in cell biology, pharmaceutics and medicine. READ MORE

  7. 15. CTA1-DD; A novel vaccine adjuvant system based on ADP-ribosyltransferase activity and B cell targeting

    Author : Lena Ågren; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera toxin; ADP-ribosyltransferase activity; adjuvant; vaccine; B cells; targeting;

    Abstract : The ADP-ribosylating enterotoxins, cholera toxin (CT) and E. coli heat-labile toxin (LT) are among the most powerful immunogens and adjuvants yet described. An innate problem, though, is their strong toxic effects, largely due to their promiscuous binding to all nucleated cells via their B-subunits. READ MORE