Search for dissertations about: "targeting"

Showing result 6 - 10 of 1708 swedish dissertations containing the word targeting.

  2. 6. Development of Substance P 1–7 Related Peptides and Peptidomimetics : Targeting Neuropathic Pain

    Author : Anna Skogh; Anja Sandström; Christian Sköld; Rebecca Fransson; Philip Thompson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance P 1–7; Peptidomimetics; Solid-phase Peptide Synthesis SPPS ; Palladium catalysis; Carbonylation; Imidazole; Bioisostere; Neuropathic pain; Allodynia; Structure-activity relationships; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The neuropeptide substance P 1–7 (SP1–7, H-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-OH) and its amidated analogue SP1–7 amide, have displayed intriguing effects in experimental models for neuropathic pain acting on a specific, yet unknown SP1–7 target. The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area. READ MORE

  4. 7. Protein targeting, translocation and insertion in Escherichia coli : Proteomic analysis of substrate-pathway relationships

    Author : Louise Baars; Jan-Willem de Gier; Jan-Maarten van Dijl; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein biogenesis; targeting; translocation; insertion; SecB; SecE; E. coli; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : Approximately 10% of the open reading frames in the genome of the Gram-negative bacterium E. coli encodes secretory proteins, and 20% encodes integral inner membrane proteins (IMPs). READ MORE

  5. 8. Knowing and Seeing the Combatant. War, Counterinsurgency and Targeting in International Law

    Author : Amin Parsa; Juridiska institutionen; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; public international law; the principle of distinction; targeting; the international law of targeting; counterinsurgency; US Army; technologies of visualisation; knowledge-vision; military uniform; disposition matrix; war; folkrätt; riktat dödande; krigets lagar; distinktionsprincipen; militär uniform; gerillabekämpning;

    Abstract : Knowing and Seeing the Combatant investigates how does the US counterinsurgent forces make distinction between civilians and combatants during targeting practices? This dissertation is specifically focused on the visual dynamics of the contemporary targeting and as such argues that the insurgent's withdrawal from the obligation of visual self-identification as targets by not wearing military uniform reveals a complicated logic of target-ability in the laws of armed conflict (LOAC).Focusing on the legal, political and visual functions of the military uniform, this dissertation argues that LOAC legitimises lethal violence by reliance on a particular conception of human target that can be summarised as a nexus of ‘knowledge – contribution to adversarial militarised willpower – and Vision – material modes of visibility and invisibility’. READ MORE

  6. 9. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy : Preclinical Studies on Head and Neck Cancer

    Author : Marika Nestor; Matti Anniko; Jörgen Carlsson; Hans Lundqvist; Vladimir Tolmachev; Matthew Robinson; Uppsala universitet; []
    Keywords : Otorhinolaryngology; antibodies; radionuclide targeting; tumour targeting; therapy; diagnostics; immuno-PET; head and neck squamous cell carcinoma; Otorhinolaryngologi;

    Abstract : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. READ MORE

  7. 10. Mining DNA elements involved in targeting of chromatin modifiers

    Author : Philge Philip; Per Stenberg; Jan Larsson; Stein Aerts; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleosome; histone; chromatin; chromatin modifiers; targeting; DNA motifs; protein factors; MSL; molekylärbiologi; Molecular Biology;

    Abstract : Background: In all higher organisms, the nuclear DNA is condensed into nucleosomes that consist of DNA wrapped around a core of highly conserved histone proteins. DNA bound to histones and other structural proteins form the chromatin. READ MORE