Search for dissertations about: "tau"

Showing result 1 - 5 of 187 swedish dissertations containing the word tau.

  1. 1. Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies

    University dissertation from Göteborgs universitet

    Author : Claudia Cicognola; Göteborgs universitet.; Gothenburg University.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tau; fragments; Alzheimer s disease; tauopathy; cerebrospinal fluid;

    Abstract : Abstract Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and dephosphorylation. READ MORE

  2. 2. Biomarkers as Monitors of Drug Effect, Diagnostic Tools and Predictors of Deterioration Rate in Alzheimer’s Disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Malin Degerman Gunnarsson; Lena Kilander; Hans Basun; Jan Marcusson; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; biomarkers; CSF; PIB PET; amyloid-beta; tau; rapid cognitive decline; dying in severe dementia; mortality; neuropsychological tests; Medicinsk vetenskap; Medical Science;

    Abstract : Decreased amyloid-ß42 (Aß42), increased total tau (t-tau) and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) reflect histopathological core changes in the most common dementia disorder, Alzheimer’s disease (AD). They discriminate AD from healthy controls and predict conversion to AD with a relatively high accuracy. READ MORE

  3. 3. Therapeutic and functional studies in animal models of Alzheimer's disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Astrid Gumucio; Lars Nilsson; Richard Cowburn; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; Immunotherapy; IntelliCage; Microtubule; Tau; Alternative splicing; Neuroscience; Neurovetenskap; Medical Cell Biology; Medicinsk cellbiologi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Senile plaques (Aβ) and neurofibrillary tangles (tau) are pathological hallmarks of Alzheimer’s disease (AD). If and how the formation of these deposits are mechanistically linked remains mainly unknown. In recent years, the focus has shifted from insoluble protein deposits to soluble aggregates of Aβ and tau. READ MORE

  4. 4. Mapping the Huntington's disease process using cerebrospinal fluid analysis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Valter Niemelä; Anne-Marie Landtblom; Dag Nyholm; Jimmy Sundblom; Edward Wild; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurodegeneration; Huntingtons disease; Neurogenetics; Neuroinflammation; Neurofilament light; tau; Proenkephalin; Neurology; Neurologi;

    Abstract : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. READ MORE

  5. 5. Proximity Ligation Assay for High Performance Protein Analysis in Medicine

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Gucci Jijuan Gu; Ulf Landegren; Thomas Joos; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein; post-translational modification; interactions; protein domain; western blotting; MARK; tau; AD; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : High quality reagents are preconditions for high performance protein analyses. But despite progress in some techniques, e.g. mass spectrometry, there is still a lack of affinity-based detection techniques with enhanced precision, specificity, and sensitivity. READ MORE