Search for dissertations about: "tauopathies"

Showing result 1 - 5 of 10 swedish dissertations containing the word tauopathies.

  2. 1. Polymorphic protein aggregation in tauopathies

    Author : Alexander Sandberg; Per Hammarström; Sofie Nyström; Wei-Feng Xue; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Alzheimer’s disease(s) comprises one of the most common and costly neurodegenerative diseases. With a larger population and an increasing life expectancy, amyloid diseases (with age as one of the most prominent risk factors) will generate an even larger burden on healthcare. READ MORE

  4. 2. A stargazer's guide to neurodegeneration : Astrocytes' role in the propagation of pathological proteins

    Author : Tobias Mothes; Anna Erlandsson; Martin Ingelsson; Linn Streubel-Gallasch; Maria Grazia Spillantini; Uppsala universitet; []
    Keywords : Alzheimer’s disease; Parkinson’s disease; tauopathies; astrocyte; microglia; neuron; tau; amyloid-β; α-synuclein; accumulation; degradation; inflammation; spreading; seeding.; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of pathogenic protein aggregates. In the AD brain, amyloid-β (Aβ) and tau form plaques respective tangles, while in the PD brain α-synuclein (α-syn) form Lewy bodies and Lewy neurites. READ MORE

  5. 3. Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies

    Author : Claudia Cicognola; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tau; fragments; Alzheimer s disease; tauopathy; cerebrospinal fluid;

    Abstract : Abstract Tau protein is physiologically expressed in neurons, where it is involved in microtubule assembly and stability. Tau functions are rigorously regulated by a series of modifications, e.g. phosphorylation and dephosphorylation. READ MORE

  6. 4. Novel cerebrospinal fluid and blood tau biomarkers in Alzheimer's disease and other neurodegenerative diseases

    Author : Juan Lantero Rodriguez; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tau; Phosphorylation; Biomarkers; Alzheimer’s disease; CSF; Blood;

    Abstract : Tau is a protein predominantly expressed in neurons in the central nervous system (CNS), where it binds microtubules (MT), playing a major role regulating their dynamics and architecture. Under pathological conditions, tau detaches from MTs, leading to neuronal dysfunction and cell death. READ MORE

  7. 5. Molecular aspects of tau proteins in Alzheimer's disease and frontotemporal dementia

    Author : Martin Ingelson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Due to aggregation in the brain of dysfunctional tau proteins, both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are referred to as tauopathies, an entity also including a number of other neurodegenerative disorders. In tauopathies, the normal microtubule-supportive function of tau is compromised, e.g. READ MORE