Search for dissertations about: "tb hiv drugs effect"

Showing result 1 - 5 of 8 swedish dissertations containing the words tb hiv drugs effect.

  2. 1. Pharmacokinetic and pharmacogenetic aspects of drug-drug interactions between antiretroviral and anti-tuberculosis drugs in Ethiopian patients : implication for optimization of TB-HIV co-treatment

    Author : Abiy Habtewolde Eyakem; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : TB and HIV are immuno-pathologically interacting epidemic infectious diseases affecting the lives of millions globally & sub-Saharan African region accounts the highest burden of both diseases. Although effective therapies are available for the management of each, TB-HIV co-treatment has faced challenges mainly due to drug-drug interactions & overlapping drug toxicities. READ MORE

  4. 2. HIV treatment outcomes in Uganda : the impact of baseline characteristics and variability in pharmacokinetics and pharmacogenetics of antiretroviral drugs

    Author : Sarah Nanzigu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ART Outcomes;

    Abstract : Guidelines specify criteria for initiation and monitoring of antiretroviral treatment (ART), including options for first line regimens. Immunological progress remains a widely used form of HIV/ART monitoring and efavirenz, a preferred first line antiretroviral drug. READ MORE

  5. 3. Tuberculosis and HIV interaction in Ethiopian children : aspects on epidemiology, diagnosis and clinical management

    Author : Ingela Berggren Palme; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Tuberculosis; HIV; Ethiopia; Child; Epidemiology; Risk factor; Mycobacterium tuberculosis; Drug resistance; Molecular epidemiology; BCG; Nutrition; Treatment; Cure rate;

    Abstract : This thesis investigates the influence of HIV on childhood tuberculosis (TB) in a high TB and HIV endemic setting. It is based on four studies involving the same study population of 522 tuberculous children and their 25 3 non-tuberculous controls, consecutively enrolled as out- and inpatients at the major paediatric hospital in Addis Ababa, Ethiopia. READ MORE

  6. 4. Pharmacogenetic aspects of HIV/AIDS, tuberculosis and malaria : emphasis on Ugandan population

    Author : Jackson Kijumba B Mukonzo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Infectious diseases such as HIV, tuberculosis and malaria are endemic in Africa and often require concomitant treatments that may result into subsequent drug–drug interactions. Inter-individual variability in the pharmacokinetics and pharmacodynamics of drugs used in infectious diseases, as a result of genetic polymorphism, has been reported. READ MORE

  7. 5. The Role of Nitric Oxide in Host Defence Against Mycobacterium tuberculosis : Clinical and Experimental Studies

    Author : Jonna Idh; Thomas Schön; Olle Stendahl; Åse Bengård Andersen; Linköpings universitet; []
    Keywords : ;

    Abstract : Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), responsible for significant morbidity and mortality worldwide, especially in low-income countries. Considering aggravating factors, such as HIV co-infection and emerging drug resistance, new therapeutic interventions are urgently needed. Following exposure to M. READ MORE