Search for dissertations about: "tdp 43"
Showing result 1 - 5 of 10 swedish dissertations containing the words tdp 43.
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1. Investigation of the intercellular transmission of α-synuclein, amyloid-β and TDP-43
Abstract : Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are disorders characterized by the progressive deposition of proteinaceous inclusions throughout the brain in a predictable manner. Each disease is described by the involvement of different misfolded and aggregated proteins (AD, amyloid-β and tau; PD, α-synuclein; ALS and FTLD, TDP-43) that spread between anatomically connected brain regions, causing cell death in previously healthy regions. READ MORE
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2. RNA binding proteins and epigenetics in SCA7
Abstract : Polyglutamine diseases are a group of nine disorders that includes, among others SCA7. The common denominator is an expanded glutamine tract in the respective disease protein caused by unstable replication during meiosis. READ MORE
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3. Frontotemporal dementia - symptoms and brain pathology
Abstract : Frontotemporal dementia (FTD) is the clinical term for a heterogeneous group of dementia disorders with symptoms emerging from frontotemporal lobar degeneration (FTLD). FTD encompasses the behavioural variant (bvFTD) and the progressive aphasias: progressive non-fluent aphasia (PNFA) and semantic dementia (SD). READ MORE
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4. Computational and chemical approaches to drug repurposing
Abstract : Drug repurposing, which entails discovering novel therapeutic applications for already existing drugs, provides numerous benefits compared to conventional drug discovery methods. This strategy can be pursued through two primary approaches: computational and chemical. READ MORE
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5. Genetic characterization of patients with frontotemporal dementia and amyotrophic lateral sclerosis in the Nordic countries
Abstract : Frontotemporal dementia (FTD) is the second most common form of neurodegenerative disease affecting people under the age of 65 years. The general symptoms are dysfunctions in behavior and/or language. READ MORE