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Showing result 1 - 5 of 20 swedish dissertations matching the above criteria.

  2. 1. Molecular Radionuclide Imaging Using Site-specifically Labelled Recombinant Affibody Molecules : Preparation and Preclinical Evaluation

    Author : Sara Ahlgren; Vladimir Tolmachev; Anna Orlova; Göran Hedenstierna; Joachim Feldwisch; Raymond Reilly; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molecular radionuclide imaging; Affibody molecules; HER2; cancer detection; radiolabelling; technetium; indium; cobalt; SPECT; PET; Oncology; Onkologi; Diagnostic radiology; Diagnostisk radiologi; Radiation biology; Strålningsbiologi; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap; Medicinsk vetenskap; Medical Science;

    Abstract : Radionuclide molecular imaging is an emerging multidisciplinary technique that is used in modern medicine to visualise diseases at cellular and molecular levels. This thesis is based on five papers (I-V) and focuses on the development of site-specific radiolabelled recombinant anti-HER2 Affibody molecules and preclinical evaluations in vitro and in vivo of the labelled conjugates. READ MORE

  4. 2. Studies of Long-lived Radionuclides in the Environment - with Emphasis on 99Tc, 237Np and Pu Isotopes

    Author : Patric Lindahl; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nuclear medicine; radiobiology; Nukleärmedicin; radiobiologi; atomic ratio; environmental samples; nuclear weapons fallout; Chernobyl fallout; bioindicators; activated carbon; Sellafield; plutonium; neptunium; ICP-MS; technetium;

    Abstract : Studies of the long-lived anthropogenic radionuclides 99Tc, 237Np, 239Pu and 240Pu were performed in marine and terrestrial areas contaminated by different accidental and controlled releases of radioactive materials. The three main sources discussed in this thesis are nuclear weapons tests, nuclear reprocessing plants and the Chernobyl accident. READ MORE

  5. 3. Deposition and absorption of inhaled drugs

    Author : Eva Bondesson; Malmö Klinisk fysiologi och nuklearmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; technetium-99m; radionuclide imaging; radioactive aerosol; powder inhaler; pharmacokinetics; mucociliary clearance; lung deposition; gamma scintigraphy; inhalation; deposition modelling; drug absorption; absorption enhancer; aerosol; medicinsk instrumentering; Physiology; Fysiologi;

    Abstract : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. READ MORE

  6. 4. Tick-borne encephalitis : on pathogenesis and prognosis

    Author : Göran Günther; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Human; tick-borne encephalitis; viral; meningo-encephalitis; cerebrospinal fluid; PCR; cytokines; immunoglobulin; SPECT; technetium-99m-HMPAO;

    Abstract : The general aim of the five studies presented in this thesis was to investigate the clinical outcome and prognosis and factors of importance for the pathogenesis of TBE compared to other aseptic meningo-encephalitis. In a prospective study 149 patients presenting with clinical symptoms of acute viral meningo-encephalitis between June 1991 and December 1993 were included. READ MORE

  7. 5. Cardiac side-effects of adjuvant radiotherapy for early breast cancer

    Author : Gábor Gyenes; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Early breast cancer; Radiation therapy; Ischemic heart disease; Side-effects; Microvascular domage; Long-term effects; Myocardial disease; Technetium 99-m sestamibi perfusion scintigraphy; Prospective study;

    Abstract : It is well established that adjuvant radiotherapy (RT) reduces loco-regional recurrences in breast cancer. The effect on overall survival on the other hand is much debated. READ MORE