Search for dissertations about: "telomerase"

Showing result 11 - 15 of 70 swedish dissertations containing the word telomerase.

  2. 11. Cell-penetrating peptides and oligonucleotides : Design, uptake and therapeutic applications

    Author : Andrés Muñoz-Alarcón; Ülo Langel; Sandrine Sagan; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; oligonucleotides; scavenger receptors; telomerase; gene therapy; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Regulation of biological processes through the use of genetic elements is a central part of biological research and also holds great promise for future therapeutic applications. Oligonucleotides comprise a class of versatile biomolecules capable of modulating gene regulation. READ MORE

  4. 12. Oncogenic Pathways and Molecular Prognostics in Neuroblastoma

    Author : Kristoffer von Stedingk; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Prognostics; Telomerase; snoRNP; miR-17-92; TGF-β; Notch; Hypoxia; Angiogenesis;

    Abstract : Neuroblastoma is an embryonal malignancy that accounts for 15% of all cancer related deaths amongst children. Although the overall survival of patients has been improving over the last decades, the high-risk neuroblastoma patients have a survival rate of ... READ MORE

  5. 13. Telomerase related studies in thyroid cancer

    Author : Martin Harper Hysek; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Follicular thyroid neoplasms are diagnostically challenging. On histologic evaluation, it can be difficult, resource-consuming, and observer-dependent to pinpoint the exact location of capsular or vascular invasion. READ MORE

  6. 14. Telomerase activity and its regulation in malignant hematopoietic cells

    Author : Dawei Xu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : hTERT mortalization malignancy activity telomerase regulation;

    Abstract : Telomerase, a multicomponent ribonucleoprotein, synthesizes TTAGGG telomeric repeats essential for the stability and integrity of chromosomes. Most normal human somatic cells exhibit undetectable telomerase activity. READ MORE

  7. 15. Telomerase in hematological and other malignancies : therapeutic implications

    Author : Bingnan Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Telomere is a nucleoprotein complex consisting of TTAGGG repeated sequences covered by specialized binding proteins termed shelterins masking the end of linear chromosomes and thereby protecting the end of the chromosome from genomic instability. Telomeres become progressively shortened during cellular replication and acts as a mitotic clock to confer a limited lifespan to normal cells. READ MORE