Search for dissertations about: "telomere length"

Showing result 21 - 25 of 46 swedish dissertations containing the words telomere length.

  2. 21. A short story of the long telomere : evidence in aging epidemiology

    Author : Yiqiang Zhan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Telomeres are the sequences of nucleotides at the end of chromosomes. Each time a cell divides, telomeres become shorter. The length of telomeres can be replenished by an enzyme, telomerase. Telomere shortening is hypothesized as the biological origin of aging. READ MORE

  4. 22. Cellular consequences of preterm birth : telomere biology, immune development and oxidative stress

    Author : Ewa Henckel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Preterm infants are at risk for oxidative stress just by being born. The extra-uterine environment is relatively oxygen-rich, their antioxidant defenses are immature, diseases and treatments in the neonatal period will trigger inflammatory responses. READ MORE

  5. 23. The role of telomerase reverse transcriptase (TERT) in human malignancies : genetic regulation and telomere lengthening-independent oncogenic activities

    Author : Jingya Yu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Telomerase is a ribonucleoprotein enzyme maintaining telomere length. Telomerase reverse transcriptase (TERT), which acts as a catalytic unit, is tightly repressed in differentiated human cells while activated in cancer cells for telomere lengthening. READ MORE

  6. 24. Towards ribozyme-mediated gene therapy of HIV-1 infections

    Author : Graham Hotchkiss; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ribozymes; HIV-1; Telomere length; HAART; Gene Therapy;

    Abstract : HIV-1 is the causative agent in AIDS, the world's fourth most frequent cause of death. HIV is a retrovirus that primarily infects macrophages and T helper cells - required for a proper immune response. READ MORE

  7. 25. Molecular ecology of marine mammals

    Author : Morten Tange Olsen; Per Palsbøll; Martine Bérubé; William “Bill” Amos; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Marine mammals; molecular ecology; life history; environmental change; phenotypic plasticity; SNPs; telomeres; molekylärgenetik; Molecular Genetics;

    Abstract : Marine mammals comprise a paraphyletic group of species whose current abundance and distribution has been greatly shaped by past environmental changes and anthropogenic impacts. This thesis describes molecular ecological approaches to answer questions regarding habitat requirements, genetic differentiation, and life-history trade-offs in three species of marine mammals. READ MORE