Search for dissertations about: "telomeric overhang"

Showing result 1 - 5 of 6 swedish dissertations containing the words telomeric overhang.

  2. 1. Telomeric DNA in Chironomus, a naturally telomerase-free system

    Author : Monika Rosén; Udo Häckers grupp Utvecklingsbiologi i invertebrater; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Chironomus; extrachromosomal telomeric repeats; RNA-DNA complex; 3´overhang; telocentric chromosome end; Telomere; complex repeats; Biologi; Genetics; cytogenetics; Genetik; cytogenetik;

    Abstract : Telomeres are specialized complexes of DNA and associated proteins that protect the ends of eukaryotic chromosomes. Although most organisms have short repeated DNA sequences at their telomeres, which are specified and maintained by the enzyme telomerase, there are a few exceptions. READ MORE

  4. 2. Saccharomyces castellii: A new model organism for telomere research

    Author : Eimantas Astromskas; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Naumovia castellii; Saccharomyces castellii; yeast; genetic tools; gene targeting; telomere; CDC13.; telomeric overhang;

    Abstract : Telomeres are natural ends of eukaryotic chromosomes and perform a major role in cell biology. They protect chromosomes from degradation, fusions and the end replication problem. To study telomeres different model organisms are used including a number of yeast species. READ MORE

  5. 3. Functional Studies of Telomere-Binding Proteins in Saccharomyces castellii

    Author : Jenny Rhodin; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Rap1; DNA-binding domain; telomere evolution; Cdc13; telomerase; single-stranded overhang; telomere; yeast; Naumovia castellii; Saccharomyces castellii;

    Abstract : Telomeres are the ends of linear eukaryotic chromosomes. The telomeres are essential for solving the end replication problem and they stabilize the genome by protection from degradation. The telomeres also protect the chromosomal ends from by being recognized as DNA breaks by the repair machinery, which could lead to end-to-end fusions. READ MORE

  6. 4. The maintenance of telomeres in the budding yeast Naumovozyma castellii

    Author : Humberto Itriago; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Telomere; Telomere dynamics; Telomere-Binding Proteins; Cdc13; Rap1; RAD52; Rad51; Homologous recombination; ALT; Budding yeast; Naumovozyma castellii;

    Abstract : Linear chromosomes of eukaryotic cells require the presence of functional nucleoprotein terminal structures, known as telomeres, to protect the integrity of the genome. The telomere is a highly dynamic and regulated structure constituted by short tandem DNA repeats rich in guanine nucleotides that extent as double-stranded DNA ending in a single-stranded 3′ overhang. READ MORE

  7. 5. Molecular characterization of the interplay between DNA-PK and TRF2 in telomere protection

    Author : Beatrice Toia; Francisca Lottersberger; Anita Öst; Grazia Daniela Raffa; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The genetic material of mammalian cells is organized as linear chromosomes inside their nucleus. In order to preserve genomic stability, mammalian cells have developed several mechanisms to detect and repair DNA lesions that can occasionally occur in the genome. READ MORE