Search for dissertations about: "tertiary alcohol"

Showing result 1 - 5 of 15 swedish dissertations containing the words tertiary alcohol.

  2. 1. Tertiary Alcohol- or β-Hydroxy γ-Lactam-Based HIV-1 Protease Inhibitors : Microwave Applications in Batch and Continuous Flow Organic Synthesis

    Author : Per Öhrngren; Mats Larhed; Knud J. Jensen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; HIV; AIDS; protease inhibitor; aspartic protease; lactam; tertiary alcohol; continuous-flow; microwave; non-resonant; MAOS; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Since the outbreak of the HIV/AIDS pandemic in the 1980s, the disease has cost the lives of over 30 million people, and a further 33 million are currently living with the HIV infection. With the appropriate treatment, HIV/AIDS can today be regarded as a chronic but manageable disease. READ MORE

  4. 2. Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic

    Author : Jenny Ekegren; Anders Hallberg; Daniel Rich; Uppsala universitet; []
    Keywords : Chemistry; HIV AIDS; HIV-1 protease inhibitor; transition-state mimic; tertiary alcohol; palladium; cross-coupling; aminocarbonylation; microwave; molybdenum hexacarbonyl; Kemi;

    Abstract : HIV-1 protease inhibitors are important in the most frequently used regimen for the treatment of HIV/AIDS, the highly active antiretroviral therapy (HAART). For patients with access to this treatment, an HIV infection is no longer lethal, but rather a manageable, chronic infection. READ MORE

  5. 3. Development of HIV-1 Protease Inhibitors and Palladium-Catalyzed Synthesis of Aryl Ketones and N-Allylbenzamides

    Author : Linda Axelsson; Mats Larhed; Anders Karlén; Luke Odell; Morten Grötli; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; palladium; aminocarbonylation; aryl ketones; decarboxylation; HIV; protease inhibitor; tertiary alcohol; macrocycles; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The use of palladium-catalyzed reactions to introduce new carbon-carbon bonds is a fundamental synthetic strategy that has been widely embraced due to its high chemo- and regioselectivity and functional group tolerance. In this context, Pd(0)-catalyzed aminocarbonylations using Mo(CO)6 instead of toxic and gaseous CO and with allylamine as the nucleophile were investigated. READ MORE

  6. 4. Biotransformations of Turpentine Constituents : Oxygenation and Esterification

    Author : Marica Lindmark-Henriksson; KTH; []
    Keywords : Picea abies; Pinaceae; Essential oils composition; Terpene alcohol; Hemiacetal; Hemiacetal ester; TMP-turpentine; Monoterpene; alpha-pinene; beta-pinene; Limonene; Verbenol; Pinocarveol; Borneol; Myrtenol; Suspension cell culture; Biotransformation; ;

    Abstract : This thesis describes methods to obtain value–addedcompounds from TMP-turpentine obtained from the spruce, Piceaabies. The methodology focuses on biotransformations using twoapproaches: an oxygenation approach (i.e. oxygenation ofterpene hydrocarbons by cell cultures) and an esterificationapproach (i. READ MORE

  7. 5. Synthesis of Organofluorine Compounds and Allenylboronic Acids - Applications Including Fluorine-18 Labelling

    Author : Denise N. Meyer; Kálmán J. Szabó; Dominique Cahard; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; boron; allenylboronic acid; BINOL; homopropargyl alcohol; organocatalyst; organoboron; organofluorine; fluorine; fluorine-18; late-stage; labelling; labeling; nucleophilic; electrophilic; fluorination; positron emision tomography; PET; radiotracer; hypervalent iodine; benziodoxole; benzoxazepines; diaryliodonium salt; metal-free; neutrophil elastase; NE; neutrophil elastase inhibitor; trifluoromethylation; trifluoromethylthiolation; difluoro enol silyl ethers; organisk kemi; Organic Chemistry;

    Abstract : This work is focused on two areas: the chemistry of organofluorine and organoboron compounds. In the first chapter, a copper-catalysed synthesis of tri- and tetrasubstituted allenylboronic acids is presented. Extension of the same method leads to allenylboronic esters. READ MORE