Search for dissertations about: "tetrahydrobiopterin"
Showing result 1 - 5 of 6 swedish dissertations containing the word tetrahydrobiopterin.
-
1. The importance of nitric oxide availability in myocardial ischemia-reperfusion injury : regulatory roles of arginase, L-arginine and tetrahydrobiopterin
Abstract : Background. Maintenance of nitric oxide (NO) availability is crucial for cardiovascular homeostasis and protection against myocardial ischemia-reperfusion (IR) injury. READ MORE
-
2. On endothelial function in type 2 diabetic patients with coronary artery disease
Abstract : Patients with type 2 diabetes have a poor outcome suffering a myocardial infarction (MI). Endothelial dysfunction may play a role in this poor prognosis. In type 2 diabetes, endothelial dysfunction is a salient feature coexisting with obesity and insulin resistance and may be linked by the same pathophysiology, i.e. READ MORE
-
3. Theoretical studies of mononuclear non-heme iron active sites
Abstract : The quantum chemical investigations presented in this thesis use hybrid density functional theory to shed light on the catalytic mechanisms of mononuclear non-heme iron oxygenases, accommodating a ferrous ion in their active sites. More specifically, the dioxygen activation process and the subsequent oxidative reactions in the following enzymes were studied: tetrahydrobiopterin-dependent hydroxylases, naphthalene 1,2-dioxygenase and α-ketoglutarate-dependent enzymes. READ MORE
-
4. Studies on the regulation of endothelial nitric oxide synthase in endothelial dysfunction
Abstract : Ischaemic heart disease and cerebrovascular disease are the leading causes of morbidity and mortality in the world. The underlying progression of the disease is linked to a reduction in the bioavailability of nitric oxide. One factor contributing to this is an increase in the production of superoxide radicals. READ MORE
-
5. X-ray characterization of PaPheOH, a bacterial phenylalanine hydroxylase
Abstract : Many human diseases are associated with the malfunction of enzymes in the aromatic amino acid hydroxylase family, e.g. phenylketonuria (PKU), hyperphenylalaninemia (HPA), schizophrenia and Parkinson's disease. READ MORE