Search for dissertations about: "tezosentan"

Showing result 1 - 5 of 6 swedish dissertations containing the word tezosentan.

  2. 1. Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock

    Author : Anna Somell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : sepsis; endotoxin; fluid resuscitation; hypertonic saline dextran; endothelin; tezosentan;

    Abstract : Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due to hypoperfusion and inflammatory changes. READ MORE

  4. 2. Vascular effects of endothelin in experimental lung injury

    Author : Björn P Persson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : acute lung injury;

    Abstract : Acute lung injury remains a frequent and life threatening consequence of severe sepsis. This thesis has investigated the role of the endothelin (ET) system in sepsis-induced lung injury, with special reference to its effects on two hallmarks of this syndrome - formation of edema and pulmonary hypertension. READ MORE

  5. 3. Cardiac function in experimental septic and non-septic conditions with special reference to the endothelin system

    Author : David Konrad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : sepsis; cardiac; endothelin; endotoxin; levosimendan; contractility; diastolic; LVPVR.;

    Abstract : Myocardial depression in sepsis has been intensely investigated for the past 30 years and still poses a considerable issue in the intensive care units. Both systolic and diastolic dysfunction is implicated, correlating with severity of illness and mortality The importance of the endothelin (ET) system in normal physiology has been extensively studied. READ MORE

  6. 4. Factors influencing splanchnic microcirculation in animal models of endotoxaemia

    Author : Andreas Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Microcirculation;

    Abstract : Even though severe sepsis and septic shock therapy has improved in recent years, mortality remains high (22-50%). Disturbances in splanchnic organ homeostasis and increases in gut permeability have long been presumed to contribute to systemic inflammation and multiple organ dysfunction syndrome in critical illness and septic shock. READ MORE

  7. 5. Pathophysiology and treatment of chlorine gas-induced lung injury : an experimental study in pigs

    Author : Jianpu Wang; Kai Knudsen; Östergötlands Läns Landsting; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : One of the most threatening scenarios in disaster medicine is the accidental release of toxic gases with the exposure of many people. In this respect, chlorine gas remains a significant threat due to its abundant use and transport through densely populated areas in modem society. READ MORE