Search for dissertations about: "tfam"

Showing result 1 - 5 of 20 swedish dissertations containing the word tfam.

  2. 1. Regulation of Human Mitochondrial DNA Replication and Transcription

    Author : Majda Mehmedovic; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mtDNA; replication; transcription; TFAM;

    Abstract : Mitochondria are organelles in eukaryotic cells, which through oxidative phosphorylation (OXPHOS) produce most of the ATP used to drive cellular processes. The organelle contains its own genetic material, mitochondrial DNA (mtDNA), which encodes 13 key components of the OXPHOS machinery. READ MORE

  4. 2. Mitochondrial dysfunction in neurodegeneration

    Author : Mats Ekstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondria; TFAM; Parkinson s disease; neurodegeneration;

    Abstract : The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). READ MORE

  5. 3. Cellular responses to respiratory chain dysfunction

    Author : Anna Hansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondria; TFAM; cardiomyopathy; aging; reactive oxygen species ROS ;

    Abstract : Mitochondria are network-like organelles present in most mammalian cells. They contain the respiratory chain (RC) that produces the majority of the energy needed in the cell, in the form of ATP. RC deficiency can arise due to mutations in the mitochondrial DNA (mtDNA) or in nuclear genes encoding mitochondrial proteins. READ MORE

  6. 4. Molecular mechanisms for transcription in mammalian mitochondria

    Author : Martina Gaspari; Karolinska Institutet; Karolinska Institutet; []
    Keywords : mitochondria; oxidative phosphorylation; mtDNA; transcription; TFAM; TFB1M TFB2M; POLRMT; promoter recognition; CSB II;

    Abstract : The circular double stranded mitochondrial genome (mtDNA), which is about 16,600 bp in humans and 16,300 bp in mice, encodes 13 of the -90 different proteins present in the respiratory chain of mammalian mitochondria. The remaining components of the respiratory chain are encoded by nuclear genes and imported into the mitochondrial network. READ MORE

  7. 5. Life without mitochondrial DNA : studies of transgenic mice

    Author : Jianming Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcripton factor A Tfam ; cre-loxP; conditional knockout; transgenic; mitochondrial cardiomyopathy; apoptosis;

    Abstract : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. READ MORE