Search for dissertations about: "the PDGF-receptors"

Showing result 1 - 5 of 21 swedish dissertations containing the words the PDGF-receptors.

  2. 1. Examining the prostate stroma and vasculature : importance and potential as targets for therapy

    Author : Anna Johansson; Anders Bergh; Arne Östman; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration therapy; vasculature; stroma; the angiopoietins; the PDGF-receptors; mast cells; Pathology; Patologi;

    Abstract : Background. Recent studies in cancer research have focused on the reciprocal interaction between cancer cells and their microenvironment. Tumour growth is angiogenesis dependent and the rate of angiogenesis correlates with a poor prognosis in many different cancers. READ MORE

  4. 2. Modulation of PDGF receptors function by posttranslational modifications

    Author : Kehuan Wang; Carl-Henrik Heldin; Johan Lennartsson; Natalia Papadopoulos; Jean-Baptiste Demoulin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signaling; receptor tyrosine kinase; ubiquitination; DUB; STAT3; SUMO; SUMOylation; cleavage; autophagy; SQSTM1 p62; LC3; GABARAP; bafilomycin A1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. READ MORE

  5. 3. Dynamics and gene expression of growth factor receptors in human cultured skin cells : Effects of UV radiation and calcium on EGF- and PDGF-receptors

    Author : Margareta Lirvall; Gunnar Kratz; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Growth factors transmit biological signals for the stimulation of cell growth and their stimulation may be involved in turnourigenesis. It is therefore of great importance to understand growth factor receptor reactions in response to stimuli such as calcium depletion or ultraviolet radiation, which normal human cells are invariably exposed to during their growth cycle. READ MORE

  6. 4. Modulation of PDGF Receptor Signaling via the Phosphatase SHP-2 and the Docking Protein Gab1

    Author : Anders Kallin; Lars Rönnstrand; Carl-Henrik Heldin; Per Lindahl; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; PDGF; SHP-2; Gab1; chemotaxis; actin reorganization; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : x.... READ MORE

  7. 5. The Roles of Growth Factor Interactions and Mechanical Tension in Angiogenesis

    Author : Ludvig Petersson; Pär Gerwins; Filip Farnebo; Uppsala universitet; []
    Keywords : angiogenesis; myofibroblast; wound healing; VEGF; FGF; PDGF; endocan; endothelial cell; vascularization; MEDICINE; MEDICIN; Medicin; Medicine;

    Abstract : Angiogenesis, the formation of new blood vessels from preexisting ones through creation of new vessel branch points by sprouting or vessel splitting, is an important part of tissue growth in both physiological processes like wound healing and pathological conditions such as cancer. Growth factors like VEGF-A, FGF-2 and PDGF-BB are involved in both types of angiogenesis. READ MORE