Search for dissertations about: "the free-energy principle"

Showing result 1 - 5 of 9 swedish dissertations containing the words the free-energy principle.

  2. 1. Understanding molecular mechanisms of protein tyrosine kinases by molecular dynamics and free energy calculations

    Author : Yaozong Li; Kwangho Nam; Magnus Wolf-Watz; Amedeo Caflisch; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; kinase; IRK; IGF-1RK; phosphorylation; activation loop; molecular dynamics; phosphoryl transfer; alchemical free energy; dynamical network; correlation map; PCA; motion projection; Gaussian softcore; free energy landscape; kinase catalysis;

    Abstract : Background: Insulin receptor kinase (IRK) and Insulin-like growth factor 1 receptor kinase (IGF-1RK) are two important members in the large class of tyrosine kinase receptors. They play pivotalroles in the regulation of glucose homeostasis, cell proliferation, differentiation, motility, andtransformation. READ MORE

  4. 2. From Static Structures to Free Energy Landscapes: Characterizing Conformational Transitions in Biological Macromolecules

    Author : Cathrine Bergh; Erik Lindahl; Gerhard Hummer; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein conformational transitions; molecular dynamics simulations; statistical mechanics; ion channels; Proteinkonformationsövergångar; molekyldynamiksimuleringar; statistisk mekanik; jonkanaler;

    Abstract : To be alive means to temporarily counteract the fundamental dispersive driving force described by the second law of thermodynamics, eventually leading all systems to decay and disorder. In cells, this task is partly carried out by proteins - small specialized molecular machines that utilize free energy to maintain the proper functioning of the cell. READ MORE

  5. 3. Reality-based brain-computer interaction

    Author : Daniel Sjölie; Lars-Erik Janlert; Johan Eriksson; John Waterworth; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; reality-based brain-computer interaction; virtual reality; reality-based interaction; brain-computer interface; activity theory; the free-energy principle; grounded cognition; Cognitive science; Kognitionsvetenskap; Computer science; Datalogi; människa-datorinteraktion; människa-datorinteraktion;

    Abstract : Recent developments within human-computer interaction (HCI) and cognitive neuroscience have come together to motivate and enable a framework for HCI with a solid basis in brain function and human reality. Human cognition is increasingly considered to be critically related to the development of human capabilities in the everyday environment (reality). READ MORE

  6. 4. A Continuum Framework for Modeling the Excitation–Contraction Coupling of Smooth Muscle

    Author : Babak Sharifimajd; Jonas Stålhand; Anders Klarbring; Markus Böl; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : Excitation-contraction coupling of smooth muscle refers to a chain of coupled physiological processes which convert a stimulus to a mechanical response. These processes can be disassociated into ionic transport during cell membrane excitation, activation of myosin light chains, and muscle contraction caused by actin-myosin interaction (filament sliding). READ MORE

  7. 5. Structural, Kinetic and Thermodynamic Aspects of the Crystal Polymorphism of Substituted Monocyclic Aromatic Compounds

    Author : Michael Svärd; Åke Rasmuson; Hugo Meekes; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Polymorphism; crystallization; thermodynamics; kinetics; nucleation; crystallography; solubility; phase equilibria; polymorphic transformation; solution history; metastable zone; classical theory of nucleation; two-step theory of nucleation; cluster; crystal structure prediction; lattice energy; molecular mechanics; force field; electrostatic potential; potential energy hypersurface; m-aminobenzoic acid; m-hydroxybenzoic acid; Chemical engineering; Kemiteknik;

    Abstract : This work concerns the interrelationship between thermodynamic, kinetic and structural aspects of crystal polymorphism. It is both experimental and theoretical, and limited with respect to compounds to substituted monocyclic aromatics. READ MORE