Search for dissertations about: "the role of a protein in a liver disease"
Showing result 1 - 5 of 86 swedish dissertations containing the words the role of a protein in a liver disease.
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1. The Biological Importance of the Amino Acid Transporter SLC38A10 : Characterization of a Knockout Mouse
Abstract : The biggest group of transporters, the solute carriers (SLCs), has more than 400 members, and about 30% of these are still orphan. In order to decipher their biological function and possible role in disease, there is a need for characterization of these. READ MORE
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2. The role of MBOAT7 on fatty liver disease
Abstract : Non-alcoholic fatty liver disease (NAFLD) is the main health disorder in internal medicine, affecting one third of the population worldwide. Environmental and genetic factors contribute to NAFLD susceptibility and progression. READ MORE
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3. Molecular mechanisms in lymphoid restriction : securing the B lineage fate
Abstract : With the work in this thesis I have aimed to deepen the understanding of the mechanisms behind the development of different blood cell lineages with a specific focus on B cell development.To understand the interplay between extracellular signaling and transcription factor networks in early lymphoid development we investigated the functional collaborations of FLT3 and IL7R. READ MORE
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4. Colorectal Liver Metastases : Onco-surgical Strategies & Prognostic Factors
Abstract : The management of patients with colorectal cancer with liver metastases has improved over the past decades. There have been significant developments in terms of surgery, local therapies, anesthesia and oncological treatment. Nevertheless, there is no consensus on what constitutes optimal treatment strategy. READ MORE
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5. Molecular basis and structural determinants for the cellular localization of cytochrome P450 2E1
Abstract : Cytochrome P450 2E1 (CYP2E1) is the alcohol inducible member of the P450 family and has a role in gluconeogenesis under fasting conditions. However, CYP2E1 is mainly of toxicological significance and metabolizes xenobiotics to their carcinogenic and toxic metabolites and generates active oxygen species that can cause lipid peroxidation and apoptosis, processes observed in alcoholic liver disease (ALD). READ MORE