Search for dissertations about: "therapeutic antibodies"
Showing result 1 - 5 of 234 swedish dissertations containing the words therapeutic antibodies.
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1. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications
Abstract : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. READ MORE
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2. Platforms and strategies harnessing signaling pathways of multifactorial diseases by multispecific antibodies
Abstract : Abstract [ENG]Proteins govern a multitude of biological functions vital to sustain life. The ability to withstand diseases development and harboring a defense against foreign pathogens is attributed to the wonders of the immune system and the proteins and cells its comprised of. READ MORE
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3. Deciphering Binding Patterns of Therapeutic Antibodies with Immune Cells : From Method Development to Application
Abstract : Reversible binding, for example between signaling molecules and receptors on the cell surface, is one of the main means to communicate information in cellular systems. Knowledge about how molecules interact is crucial for both understanding biological function and for therapeutic intervention. READ MORE
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4. Therapeutic Cancer Vaccines Targeting Molecules Associated with Tumor Angiogenesis
Abstract : Induction of an endogenous antibody response by therapeutic vaccination could provide an alternative to cost-intensive monoclonal antibody-based treatments for cancer. Since the target of a cancer vaccine will most likely be a self-antigen, self-tolerance of the immune system must be circumvented. READ MORE
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5. On the Use of 76Br-labelled Monoclonal Antibodies for PET : Preclinical Evaluation of Halogenated Antibodies for Diagnosis and Treatment of Cancer
Abstract : Radioactive substances are used in vivo to localize and characterize malignant tumours, generally by scintigraphic methods. In this context positron emission tomography (PET) in combination with radiolabelled monoclonal antibodies (mAbs) may provide a sensitive and specific method for detection of cancer. READ MORE