Search for dissertations about: "therapeutic drug monitoring tdm"
Showing result 1 - 5 of 16 swedish dissertations containing the words therapeutic drug monitoring tdm.
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1. Therapeutic Drug Monitoring in Psychiatry : Some aspects of utility in clinical practice and research
Abstract : Background and objectives: Several new psychoactive drugs for the treatment of psychiatric disorders have been introduced onto the market since the late 1980s. Basic aspects of pharmacodynamics and pharmacokinetics (PK) are investigated before approval for general prescription. READ MORE
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2. Bioanalytical development for application in therapeutic drug monitoring : focus on drugs used in psychiatry
Abstract : Introduction: Since the 1950s and onwards, many new psychoactive drugs have been successfully introduced in clinical practice. A common feature of these drugs is a profound metabolism before clearance from the body. READ MORE
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3. Development of new methodology for therapeutic drug monitoring of thiopurine treatment
Abstract : The three thiopurine drugs azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used to treat several diseases, including inflammatory bowel disease (IBD). They are pro-drugs and are believed to act through the formation of thioguanine nucleotides (TGNs). READ MORE
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4. Individualized treatment and control of bacterial infections
Abstract : Infectious diseases cause substantial morbidity and mortality, exacerbated by increasing antibiotic resistance. In critically ill patients, recent studies indicate a substantial variability in β-lactam antibiotic levels when standardized dosing is applied. READ MORE
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5. Clinical and Pharmacological Aspects of Selective Serotonin Reuptake Inhibitors in the Treatment of Depression in Old Age
Abstract : Objective: The aim of the present thesis is to examine the pharmacokinetic and biochemical effects of the selective serotonin reuptake inhibitors (SSRIs) in the elderly.Background: Symptoms of depression are found in up to 15% of the elderly and the prevalence of major depression is reported to be about 3%. READ MORE