Search for dissertations about: "therapeutic drug monitoring"

Showing result 1 - 5 of 55 swedish dissertations containing the words therapeutic drug monitoring.

  1. 1. Therapeutic Drug Monitoring in Psychiatry Some aspects of utility in clinical practice and research

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Maria Dolores Chermá Yeste; Linköpings universitet.; Linköpings universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TDM; psychoactive drug; pharmacokinetics; pharmacogenetics; naturalistic; elderly; child; MEDICINE Physiology and pharmacology Pharmacological research Clinical pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Klinisk farmakologi;

    Abstract : Background and objectives: Several new psychoactive drugs for the treatment of psychiatric disorders have been introduced onto the market since the late 1980s. Basic aspects of pharmacodynamics and pharmacokinetics (PK) are investigated before approval for general prescription. READ MORE

  2. 2. Bioanalytical development for application in therapeutic drug monitoring : focus on drugs used in psychiatry

    University dissertation from Linköping : Linköpings universitet

    Author : Daniel Öhman; Linköpings universitet.; Linköpings universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : Introduction: Since the 1950s and onwards, many new psychoactive drugs have been successfully introduced in clinical practice. A common feature of these drugs is a profound metabolism before clearance from the body. READ MORE

  3. 3. Clinical Pharmacogenetics of Olanzapine with Focus on FMO Gene Polymorphisms

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mao Mao Söderberg; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; olanzapine; pharmacogenetics; drug metabolism; schizophrenia; therapeutic drug monitoring; FMO1; FMO3; CYP1A2; UGT1A4; Clinical Pharmacology; Klinisk farmakologi;

    Abstract : Pharmacogenetics is the study of variability in drug response attributed to genetic variation. Olanzapine (OLA) is a widely used antipsychotic drug for schizophrenia treatment. The pharmacokinetics of OLA display large inter-individual variation leading to multiple-fold differences in drug exposure between patients at a given dose. READ MORE

  4. 4. On drug use, multiple medication and polypharmacy in a national population

    University dissertation from Växjö : Linnaeus University Press

    Author : Bo Hovstadius; Linnéuniversitetet.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; drug use; multiple medication; polypharmacy; register; prevalence; therapeutic intensity; acquisition cost.; NATURAL SCIENCES; NATURVETENSKAP; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : The application of multiple medications has successively increased during a number of years and has thereby increased the potential risks of adverse drug reactions, interactions and non-adherence to drug therapy. This may result in unnecessary health expenditure, directly due to redundant drug sales, and indirectly due to the increased hospitalization caused by drug-related problems. READ MORE

  5. 5. Individualized treatment and control of bacterial infections

    University dissertation from Växjö : Linnaeus University Press

    Author : Hanna Woksepp; Linnéuniversitetet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; therapeutic drug monitoring; intensive care unit; β-lactam antibiotics; antimicrobial drug resistance; molecular typing; whole-genome sequencing; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Infectious diseases cause substantial morbidity and mortality, exacerbated by increasing antibiotic resistance. In critically ill patients, recent studies indicate a substantial variability in β-lactam antibiotic levels when standardized dosing is applied. READ MORE