Search for dissertations about: "therapeutic drug monitoring"

Showing result 6 - 10 of 66 swedish dissertations containing the words therapeutic drug monitoring.

  2. 6. Individualized treatment and control of bacterial infections

    Author : Hanna Woksepp; Thomas Schön; Anders Johansson; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; therapeutic drug monitoring; intensive care unit; β-lactam antibiotics; antimicrobial drug resistance; molecular typing; whole-genome sequencing; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Infectious diseases cause substantial morbidity and mortality, exacerbated by increasing antibiotic resistance. In critically ill patients, recent studies indicate a substantial variability in β-lactam antibiotic levels when standardized dosing is applied. READ MORE

  4. 7. Drug-drug interactions : from knowledge base to clinical impact

    Author : Marine Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Drug usage has increased steadily, and the more drugs used, the higher the risk for adverse effects or loss of effect due to drug-drug interactions. For drug prescribers it is difficult to know what drugs a patient is taking and whether they interact. READ MORE

  5. 8. Clinical and Pharmacological Aspects of Selective Serotonin Reuptake Inhibitors in the Treatment of Depression in Old Age

    Author : Jöns Lundmark; Finn Bengtsson; Leif Lindström; Linköpings universitet; []
    Keywords : Serum concentrations; cerebrospinal fluid; pharmacokinetics; selective serotonin reuptake inhibitors; therapeutic drug monitoring; elderly; depression; pharmaceutical economics; MEDICINE; MEDICIN;

    Abstract : Objective: The aim of the present thesis is to examine the pharmacokinetic and biochemical effects of the selective serotonin reuptake inhibitors (SSRIs) in the elderly.Background: Symptoms of depression are found in up to 15% of the elderly and the prevalence of major depression is reported to be about 3%. READ MORE

  6. 9. Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

    Author : Robin J. Svensson; Ulrika S H Simonsson; Mats O Karlsson; Andreas Krause; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Biomarkers; Rifampicin; Clofazimine; Therapeutic drug monitoring; Time-to-event; Time-to-positivity; Molecular bacterial load assay; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : With 10 million new infections yearly, tuberculosis has a major impact on the human well-being of the world. Most patients have infections susceptible to a first-line treatment with a treatment success rate of 80%, a number that can potentially be improved by optimising the first-line treatment. READ MORE

  7. 10. Adherence to Antidepressant Medication

    Author : Ann-Charlotte Åkerblad; Lisa Ekselius; Ingvar Krakau; Uppsala universitet; []
    Keywords : Psychiatry; adherence; depression; randomised controlled trial; intervention; therapeutic drug monitoring; personality; health status; health care utilisation; Psykiatri;

    Abstract : Non-adherence to medication is a major obstacle in the treatment of depression. The objectives of the present study were to explore the effect of two interventions aiming to increase antidepressant treatment adherence, and to examine long-term consequences and costs of depression in adherent and non-adherent primary care patients. READ MORE