Search for dissertations about: "therapeutics"

Showing result 11 - 15 of 214 swedish dissertations containing the word therapeutics.

  2. 11. Conformationally Constrained Nucleic Acids as Potential RNA Targeting Therapeutics

    Author : Zhou Chuanzheng; Jyoti Chattopadhyaya; Serge Beaucage; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Bioorganisk kemi; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

    Abstract : .... READ MORE

  4. 12. Quiescent cancer cells : Three-dimensional cell models for evaluation of new therapeutics

    Author : Frida Ek; Mårten Fryknäs; Malin Jarvius; Rolf Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; cancer cell quiescence; dormancy; three-dimensional; multicellular tumor spheroids; model development; cancer pharmacology; mitochondria; OXPHOS; colorectal carcinoma; hepatocellular carcinoma; Medicinsk vetenskap; Medical Science;

    Abstract : Inadequate metabolic conditions in solid tumors lead to the formation of quiescent cancer cells that are suspended in a transient cell cycle arrest. When conditions change, quiescent cancer cells can re-enter the cell cycle and cause recurrence. READ MORE

  5. 13. Cerebral Mitochondrial Dysfunction and the Development of Targeted Therapeutics

    Author : Michael Karlsson; Mitokondriell Medicin; []
    Keywords : mitochondria; brain; animal models; sepsis; traumatic brain injury; neuroprotection; cyclosporine;

    Abstract : .... READ MORE

  6. 14. Experimental Diagnostics and Therapeutics of Invasive Urinary Bladder Cancer

    Author : Amir Sherif; Per-Uno Malmström; Magnus Thörn; Lars Holmberg; Sten Nilsson; Michael J Droller; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Bladder cancer; Cystectomy; Neoadjuvant chemotherapy; Kirurgi; Lymph node excision; Radionuclide imaging; Gene expression; Surgery; Kirurgi; kirurgi; särskilt urologi; Urology;

    Abstract : The two purposes of this thesis were to evaluate new diagnostic techniques of lymphnode staging in invasive bladder cancer and to evaluate the results of neoadjuvant chemotherapy in invasive bladder cancer.Sentinel node detection was performed in 13 patients in preparation for radical cystectomy. READ MORE

  7. 15. Design and application of RNA therapeutics for splice site mutations

    Author : Burcu Bestas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Precursor messenger RNA splicing is one of the most fundamental and complex mechanisms in eukaryotes. Over 90% of the human genes undergo alternative splicing, which is essential for the regulation of gene expression. A dynamic RNA-protein complex called the spliceosome catalyzes splicing. READ MORE