Search for dissertations about: "therapy p53"

Showing result 1 - 5 of 92 swedish dissertations containing the words therapy p53.

  2. 1. Precision medicine and targeted therapy : Turning the tables on cancer

    Author : Anja Mortensen; Marika Nestor; Gregory Adams; Uppsala universitet; []
    Keywords : p53 cancers; PM2; radiosensitization; radio-immunotherapy; MDM2 X inhibition; combination therapy; targeted radionuclide therapy; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : An extended understanding of the molecular characteristics of cancer has led to a revolution within the field of precision medicine. This thesis explores the utilization of two targets for precision medicine, namely, CD44v6 and murine double-minute 2 and X (MDM2/X). READ MORE

  4. 2. Prognostic Factors in Early Stages (FIGO I-II) of Epithelial Ovarian Carcinoma

    Author : Ingirídur Skírnisdóttir; Seija Grenman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; Ovarian cancer; early stages; adjuvant therapy; prognosis; tumor grade; apoptotic regulators; p53; bcl-2; bax; growth factor receptors; HER-2 neu; EGFR; DNA ploidy; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; Obstetrics and Gynaecology; obstetrik och gynekologi;

    Abstract : From January, 1988, to December, 1993, 113 patients with FIGO stage IA-IIC epithelial ovarian carcinoma were treated with postoperative radiotherapy. The median follow-up period was 74 months. Tumor recurrences were recorded in 33 cases (30%). The cancer-specific survival rate was 72%. READ MORE

  5. 3. Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer

    Author : Jenny Brändstedt; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; carcinogenesis; MDCS; anthropometrics; risk factors; sex differences; hormonal therapy; beta-catenin; cyclin D1; p53; MSI; KRAS mutation; BRAF mutation;

    Abstract : Colorectal cancer (CRC) is the third most common cancer globally, with approximately 1.2 million new cases every year. The highest incidence rates are seen in developed countries, thereby imposing dietary and lifestyle factors in the etiology of CRC. READ MORE

  6. 4. Understanding p53 structure and targeting mutant p53 for improved cancer therapy

    Author : Qiang Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The p53 gene family consists of p53, p63 and p73. The three proteins share a high degree of structural similarity in their DNA-binding domains but have rather different functions. The tumor suppressor p53 acts as the guardian of the genome and is activated in response to cellular stress. READ MORE

  7. 5. Searching for Synergy : Radiosensitization of 177Lu-DOTATATE

    Author : Sara Lundsten; Marika Nestor; Hanna Björkelund; Katarina Edwards; Julie Nonnekens; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; targeted radionuclide therapy; radiosensitization; p53; MDM2 MDM4 inhibition; HSP90; drug synergy; drug delivery; lipid nanoparticles; lipodisks; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : Cancers presents a major health challenge, and there is a pressing need to develop new therapeutic strategies. Surgery, chemotherapy and radiation are the most commonly used treatments for cancer today. Radiation can be given as targeted radionuclide therapy (TRT), i.e. READ MORE