Search for dissertations about: "thermal unfolding"

Showing result 1 - 5 of 20 swedish dissertations containing the words thermal unfolding.

2. 1. Protein dynamics: aggregation and mechanical unfolding

   Author : Simon Mitternacht; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Monte Carlo simulations; All-atom protein models; Mechanical unfolding; Protein aggregation;

   Abstract : The subject of this thesis is protein dynamics. Papers I--IV and VI study either of two different processes: mechanical unfolding and aggregation. Paper V presents a computationally efficient all-atom model for proteins, variants of which are used to perform Monte Carlo simulations in the other papers. READ MORE

4. 2. Protein unfolding by interfaces and interactions between polycyclic aromatic hydrocarbons

   Author : Svetla Chakarova Käck; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; first-principles calculations; PAH; denaturation; protein-interface interactions; van der Waals interactions; lattice models; polycyclic aromatic hydrocarbons; DFT; density functional theory;

   Abstract : In order to theoretically study large and complex systems, a variety of approaches that can be categorized loosely as top-down or bottom-up are followed. While our vision is to bridge the gap between these approaches and use them together in multiscale materials modeling, the present thesis is limited to give examples of each type of approach in the study of soft-matter systems. READ MORE

5. 3. Bioactive Proteins in Bovine Milk - Studies on Glutathione Peroxidase, Lactoferrin and Immunoglobulins

   Author : Helena Lindmark Månsson; Kemiska institutionen; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; General biomedical sciences; Biokemisk teknik; Biochemical technology; thermal stability; milk processability; selenium; antioxidants; immunoglobulin; lactoferrin; Milk; glutathione peroxidase; Biomedicinska vetenskaper allmänt ; Biochemistry; Metabolism; Biokemi; metabolism;

   Abstract : Many proteins in bovine milk exhibit specific biological activity in addition to their established nutritional value as source of protein. Examples of such bioactive proteins are extracellular glutathione peroxidase, lactoferrin and immunoglobulins. READ MORE

6. 4. On the mechanism of Urea-induced protein denaturation

   Author : Matteus Lindgren; Per-Olof Westlund; Arnold Maliniak; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemical denaturation; Protein unfolding; urea; MD simulations; NMR spectroscopy; Biophysical chemistry; Biofysikalisk kemi; fysikalisk kemi; Physical Chemistry;

   Abstract : It is well known that folded proteins in water are destabilized by the addition of urea. When a protein loses its ability to perform its biological activity due to a change in its structure, it is said to denaturate. READ MORE

7. 5. Structure determination, thermal stability and catalytic mechanism of hyperthermostable isocitrate dehydrogenases

   Author : Mikael Karlström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : X-ray crystallography; isocitrate dehydrogenase; thermostability; catalytic mechanism;

   Abstract : In this thesis, studies on the enzyme isocitrate dehydrogenase (IDH) from the hyperthermophiles Aeropyrum pernix (ApIDH), Thermotoga maritima (TmIDH), Archaeoglobus fulgidus (AfIDH) and Pyrococcus furiosus (PfIDH) are presented. The aim of the described work was to contribute to the understanding of protein thermostability and to study the catalytic mechanism. READ MORE