Search for dissertations about: "thesis for brain cancer"

Showing result 11 - 15 of 243 swedish dissertations containing the words thesis for brain cancer.

  2. 11. The Molecular Epidemiology of Non-Small Cell Lung Cancer

    Author : Johan Isaksson; Johan Botling; Eva Brandén; Hirsh Koyi; Aija Knuuttila; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NSCLC; Lung Cancer; Epidemiology; Genetics; KRAS; Pathology; Biomarkers; Oncology; Onkologi;

    Abstract : The aim of this thesis was to explore the role of a spectrum of biomarkers, for disease classification or predictors of treatment outcomes in non-small cell lung cancer (NSCLC).Paper I examined the impact of systemic inflammation on the clinical outcome of NSCLC patients. READ MORE

  4. 12. Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy

    Author : Siker Kimbung; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic breast cancer; biomarker conversion; liver metastasis-selective genes; prognosis; BRCA1; PARP1;

    Abstract : Metastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecular determinants of metastasis, breast cancer relapse and death rates remain unacceptably high. READ MORE

  5. 13. Pharmacokinetic and pharmacodynamic studies on cisplatin in mice and men

    Author : Anders Johnsson; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; cancerology; oncology; Cytology; immunohistochemistry; nephrotoxicity; pharmacodynamics; pharmacokinetics; Cisplatin; DNA adducts; platinum; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : Methodological tools for studies of the cytostatic agen cisplatin (CDDP) were explored and applied to elucidate various aspects of pharmacokinetics, drug distribution, chemomodulation and pharmacodynamics. An immunohistochemical assay for analysis of CDDP-DNA adducts, i.e. READ MORE

  6. 14. Stromal and tumor cell responses to hypoxia and treatment within the glioma microenvironment

    Author : Vasiliki Pantazopoulou; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; glioblastoma; tumor microenvironment; reactive astrocytes; hypoxia; CD44; p75NTR;

    Abstract : Glioblastoma is the most aggressive primary brain tumor in adults. Despite treatment, tumors invariably recur, and the recurring tumor is resistant to therapies. New approaches are needed for the successful treatment of glioblastoma patients.Tumors are not simply a compilation of molecularly and phenotypically identical neoplastic cells. READ MORE

  7. 15. CD93 in regulation of vascular function and tumour progression

    Author : Kalyani Vemuri; Anna Dimberg; Pipsa Saharinen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD93; Tumour angiogenesis; Vascular permeability; Endothelial junctions; Cancer; Glioblastoma; Metastasis;

    Abstract : To achieve successful vascular targeting in cancer, a better understanding of the molecular mechanisms that lead to tumour vascular abnormalities is required.  The transmembrane protein CD93 is highly expressed in the vasculature of several tumours including glioblastoma and has emerged as a potential anti-angiogenic target. READ MORE