Search for dissertations about: "thesis for esophageal cancer"

Showing result 1 - 5 of 46 swedish dissertations containing the words thesis for esophageal cancer.

  1. 1. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer

    Author : Anna Isinger Ekstrand; Institutionen för Immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; hereditary cancer; HNPCC; copy number analysis; CGH; gene expression; Wnt; PIK3CA; CHEK2; gastric cancer; colorectal cancer;

    Abstract : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. READ MORE

  2. 2. Towards improved oncological treatment of esophageal and gastric cancer. Clinical and translational studies

    Author : David Borg; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal adenocarcinoma; Gastric cancer; PODXL; Prognosis; Prediction; Chemotherapy dose intensity; Dysphagia; Radiotherapy;

    Abstract : BackgroundThe overall aim of this thesis was to improve the oncological treatment strategies in esophageal and gastric adenocarcinoma (EGAC). Podocalyxin-like protein 1 (PODXL) has been associated with poor prognosis in other cancers and we wanted to investigate its potential role as a prognostic and predictive biomarker in resectable EGAC. READ MORE

  3. 3. Esophageal- and Gastroesophageal Junctional Cancer : Aspects on Staging, Treatment and Results

    Author : Gustav Linder; Jakob Hedberg; Magnus Sundbom; Wilhelm Graf; Bas P.L. Wijnhoven; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Esophageal cancer; Education level; Tonometry; Lymphadenectomy; PET MRI; Kirurgi; Surgery;

    Abstract : Esophageal- and gastroesophageal junctional (GEJ) cancer is the sixth cause of cancer-related death worldwide. Some improvements in care are attributed to nationwide disease-specific registries, preoperative staging and increased understanding of mechanisms affecting patient selection. READ MORE

  4. 4. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study

    Author : Magdalena Cwikiel; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; cell culture.; scanning and transmission electron microscopy; endothelium; lipid peroxidation; free radical; fibrinogen; 5-fluorouracil; blood and plasma viscosity; cardiotoxicity; cancerology; Cytologi; onkologi; cancer; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). READ MORE

  5. 5. Risk factors for esophageal squamous cell carcinoma

    Author : Dariush Nasrollahzadeh Nesheli; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; esophageal cancer;

    Abstract : Aims: The etiology of esophageal squamous cell carcinoma (ESCC) in the high risk areas is largely unknown and a few environmental risk factors which have been identified do not explain its oddly high incidence in esophageal cancer belt. The aims of this thesis were to investigate the association of opium/tobacco consumption, serologic gastric atrophy, gastric mucosa-associated microbiota and contact with farm animals with the risk of ESCC. READ MORE