Search for dissertations about: "thesis for ewings"
Showing result 1 - 5 of 6 swedish dissertations containing the words thesis for ewings.
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1. Detection of fusion genes and fusion proteins in sarcoma : methodological and clinical aspects
Abstract : Ewing's sarcoma/PNET and synovial sarcoma, all regarded as high-grade tumours, have their peak incidence during the second decade of life, thus affecting children and adolescents. Both tumour types have specific chromosomal translocations, i.e. t(11;22) and t(X;18), respectively, resulting in fusion genes coding for chimeric proteins. READ MORE
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2. Fine needle aspiration cytology in diagnosis and management of childhood small round cell tumours
Abstract : Fine needle aspiration (FNA) cytology is accepted for diagnosing malignant tumours in adults. However, it has been slow in gaining acceptance among paediatricians and has only been used at some centres in the routine diagnosis of childhood tumours. READ MORE
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3. Protein modification with hydrophobic prenyl groups in malignant cells
Abstract : Mevalonate (MVA) is the key intermediate in the isoprene synthetic pathway leading to the formation of a number of biologically important lipid molecules. It is well known that inhibition of MVA synthesis blocks the cell cycle progression of mammalian cells, a fact suggesting that some isoprenoids derived from MVA are required for cell proliferation. READ MORE
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4. Growth factor pathways in human cancer : functional and therapeutic implications
Abstract : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. READ MORE
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5. Old receptors learn new tricks : biasing anti-IGF1R cancer therapy through the GPCR system
Abstract : As cancers progress, tumor cells exploit the extracellular signals generated from plasma membrane receptors for cell growth, migration, and anti-apoptosis. G protein-coupled receptors (GPCR) and receptor tyrosine kinases (RTKs) are two important families of plasm membrane receptors, controlling multiple biological functions via their downstream signaling. READ MORE