Search for dissertations about: "thesis in bioinformatics"

Showing result 1 - 5 of 630 swedish dissertations containing the words thesis in bioinformatics.

2. 1. A Study in RNA Bioinformatics : Identification, Prediction and Analysis

   Author : Eva Freyhult; David Ardell; Robert Giegerich; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA; bioinformatics; secondary structure; structure prediction; dynamic programming; energy landscape; homology search; sequence logo; tRNA; Bioinformatics; Bioinformatik;

   Abstract : Research in the last few decades has revealed the great capacity of the RNA molecule. RNA, which previously was assumed to play a main role only as an intermediate in the translation of genes to proteins, is today known to play many important roles in the cell in addition to that as a messenger RNA and transfer RNA, including the ability to catalyze reactions and gene regulations at various levels. READ MORE

4. 2. eScience Approaches to Model Selection and Assessment : Applications in Bioinformatics

   Author : Martin Eklund; Jarl Wikberg; Ron Wehrens; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; high-throughout biology; eScience; model selection; model assessment; Bioinformatics; Bioinformatik;

   Abstract : High-throughput experimental methods, such as DNA and protein microarrays, have become ubiquitous and indispensable tools in biology and biomedicine, and the number of high-throughput technologies is constantly increasing. They provide the power to measure thousands of properties of a biological system in a single experiment and have the potential to revolutionize our understanding of biology and medicine. READ MORE

5. 3. Improved Neuropeptide Identification : Bioinformatics and Mass Spectrometry

   Author : Maria Fälth Savitski; Per Andrén; David Fenyö; Per Svenningsson; Ronald Beavis; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; neuropepides; database; peptide identification; peptide fragmentation; mass spectrometry; tandem mass spectromerty; Bioinformatics; Bioinformatik;

   Abstract : Bioinformatic methods were developed for improved identification of endogenous peptides using mass spectrometry. As a framework for these methods, a database for endogenous peptides, SwePep, was created. It was designed for storing information about endogenous peptides including tandem mass spectra. READ MORE

6. 4. Human leukocyte antigen in sickness and in health : Ankylosing spondylitis and HLA in Sweden

   Author : Jessika Nordin; Kerstin Lindblad-Toh; Jennifer Meadows; Matthew Webster; Alison Meynert; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Disease genetics; Ankylosing spondylitis; HLA typing; Imputation; Inference; Sex-stratified; HLA-B*27 independent; Association tests; Functional validation; Bioinformatics; Bioinformatik; Molekylär genetik; Molecular Genetics;

   Abstract : The human leukocyte antigen (HLA) plays a major role in keeping us healthy, but some of the HLA alleles can contribute to disease susceptibility. One example is HLA-B*27, which confers increased susceptibility of ankylosing spondylitis and represents one of the strongest genetic associations found in any common human disease. READ MORE

7. 5. Fusing Domain Knowledge with Data : Applications in Bioinformatics

   Author : Claes Andersson; Jan Komorowski; Mats Gustafsson; Yves Moreau; Uppsala universitet; []
   Keywords : Bioinformatics; cell cycle; cancer chemotherapy; predictive tests; performance estimation; bioinformatics; Bioinformatik;

   Abstract : Massively parallel measurement techniques can be used for generating hypotheses about the molecular underpinnings of a biological systems. This thesis investigates how domain knowledge can be fused to data from different sources in order to generate more sophisticated hypotheses and improved analyses. READ MORE