Search for dissertations about: "thesis in monoclonal antibody"
Showing result 1 - 5 of 279 swedish dissertations containing the words thesis in monoclonal antibody.
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1. T lymphocytes in autoimmune arthritis : monoclonal antibody treatments in mouse and rat
Abstract : .... READ MORE
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2. Immunomodulatory Therapy of Solid Tumors : With a Focus on Monoclonal Antibodies
Abstract : Cancer, historically considered a genetic disease, is currently acknowledged to affect the whole body. Our immune system is one key player that can elicit a response against malignant cells but can also promote tumorigenesis. Tumors avoid immune recognition by creating a suppressive microenvironment and inducing tolerance. READ MORE
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3. Engineering Antibody Specificity Using Combinatorial Antibody Libraries
Abstract : The research presented in this thesis investigates antibody specificity, antibody-antigen and protein-protein interactions using combinatorial antibody libraries, phage-display and bacterial display technology. One goal was to develop a method to generate antibodies that bind two protein antigens with high affinity using a single-antigen binding site, and to investigate the molecular and thermodynamic requirements for antibody multispecificity. READ MORE
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4. Development and evaluation of analytical techniques for antibodies and antibody-drug conjugates : From verification of conjugation to stability testing
Abstract : Antibody-drug conjugates (ADCs) are becoming increasingly important in oncology. ADCs are inherently heterogeneous analytes. For a successful drug candidate to go through to the clinic, extensive characterization and evaluation of the constructs are necessary. READ MORE
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5. Exploring Monoclonal Antibody Action Against the Group A Streptococcal M Protein
Abstract : Group A Streptococcus (GAS) is a significant human pathogen that has developed multipleimmune evasion mechanisms to counter the host immune response. One of these mechanisms involvesthe production of the M protein, which, amongst other things, acts as an anti-phagocytic factor and canbind host proteins. READ MORE