Search for dissertations about: "thesis of Trisomy 8 in acute myeloid leukemia"

Found 4 swedish dissertations containing the words thesis of Trisomy 8 in acute myeloid leukemia.

  2. 1. Trisomies in Hematologic Malignancies

    Author : Kajsa Paulsson; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; Klinisk genetik; cytogenetik; Genetik; cytogenetics; Genetics; leukemia; chromosome aberration; trisomy;

    Abstract : Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.. READ MORE

  4. 2. Cytogenetic abnormalities in Acute Myeloid Leukemia in Sweden. A population based study

    Author : Vladimir Lazarevic; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AML; karyotype; population-based studies; prognosis; chromosomes; hyperdiploidy;

    Abstract : The impact of cytogenetic findings in AML was analyzed in the large population-based Swedish AML registry. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotype (CK) were more common in older patients. READ MORE

  5. 3. Chromosome aberrations and environmental exposures in acute leukemia

    Author : Ragnhild Rosengren Lindquist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute leukemia; chromosome 3; chromosome 8; fragile site; occupational exposure; mutagen exposure; case-control study; trisomy; benzene; organic solvent; petroleum; epidemiology; environmental carcinogens; painter; driver;

    Abstract : The aims of this thesis are to evaluate the role of environmental exposures, especially professional exposure to organic solvents and petroleum products in the etiology of acute leukemia and to investigate if there is a correlation between the exposure to a specific leukemogen factor and a clonal chromosome aberration of the leukemic cells. Papers I and II present results of a case-control study of environmental exposures, in all occupations during life-time, medical treatments with medicines, chemotherapy and radiation, tobacco-use and the exposure to chemical compounds in private life in 120 patients with acute leukemia and of 120 controls, matched for age (+ 4 years), residence and sex. READ MORE

  6. 4. Case-control studies on risk factors for myeloid leukemias and myelodysplastic syndromes

    Author : Jonas Björk; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epidemiologic methods; bias epidemiology ; attributable fraction; smoking; hobbies; occupational exposure; chromosome aberrations; epidemiology; cytogenetic; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Abstract : Case-control studies comprising telephone interviews for 333 cases of acute myeloid leukemia (AML), 226 cases of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), 330 cases of myelodysplastic syndromes (MDS), and matched controls were conducted. Information had to be obtained from next-of-kin much more often for cases (85%) than for controls (18%). READ MORE