Search for dissertations about: "thesis on PROTEASE"

Showing result 1 - 5 of 346 swedish dissertations containing the words thesis on PROTEASE.

  1. 1. Characterization of conjugated protease inhibitors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Erika Billinger; Gunnar Johansson; Boris Turk; [2020]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Serine protease inhibitors; conjugation; immobilization; leupeptin analogues; potato serine protease inhibitor; soluble carriers; inorganic carriers.; Biokemi; Biochemistry;

    Abstract : The overall theme of this thesis is a step by step approach for the design and characterization of conjugated protease inhibitors. This involves both a new assay method for protease activity and protease inhibition (paper I), a study of the stoichiometry for protease inhibitor interaction (paper II), design of inhibitory peptides (paper IV) and the construction of inhibitor conjugates (paper III & IV). READ MORE

  2. 2. Development of the gastrointestinal tract in young mammals : Effects of enteral provocation with protease or phytohaemagglutinin in neonatal rats

    University dissertation from Lund University, Faculty of Science, Department of Biology

    Author : Ester Arevalo Sureda; [2017-03]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; gut; Intestine; Pancreas; development; precocious; protease; PHA; enterocytes; permeability; endocytosis; IgG; FcRn; Blimp1; T-lymphocyte; passive immunity; altricial; neonatal; suckling; athymic; rat; immunohistochemistry IHC ;

    Abstract : The rat, as an altritial species, is born with an immature gastrointestinal tract and intestinal barrier function, which is highly absorptive to milk-borne bioactive molecules that can pass undigested and reach the general circulation of the suckling newborn. This passage occurs by the neonatal-Fc-receptor (FcRn) binding and trancytosis of immunoglobulin G in the proximal small intestine (SI) and by the highly endocytic vacuolated enterocytes non-selectively in the distal SI. READ MORE

  3. 3. Regulation of photosynthesis -Cytochrome b6f in redox regulation -Two novel proteases acting on an N-terminal peptide of LHCII

    University dissertation from Department of Plant Biochemistry, Lund University

    Author : Jörgen Ström; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plant biochemistry; Växtbiokemi; cGEP; proteolysis; protease; protein phosphorylation; redox regulation; light-harvesting antenna; cytochrome b6f; chloroplast; Photosynthesis;

    Abstract : In higher plants photosynthesis takes place in the chloroplast. This work focuses on two different processes that effects photosynthesis. Firstly, we studied the events occurring prior to the phosphorylation of LHCII. Secondly, we also studied two novel proteases, with the potential to degrade LHCII. READ MORE

  4. 4. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library

    University dissertation from Institutionen för fysik, kemi och biologi

    Author : Fredrik Thorstensson; Ingemar Kvarnström; Charles Hedgecock; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; organic synthesis; combinatorial synthesis; metathesis; olefin metathesis; thrombin; HCV; NS3; protease; proline isosteres; inhibitor; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes;

    Abstract : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. READ MORE

  5. 5. Ageing-associated changes of lysosomal compartment implications on cellular functions

    University dissertation from Institutionen för nervsystem och rörelseorgan

    Author : Yuri Stroikin; Ulf Brunk; Alexei Terman; Karin Öllinger; Suresh Rattan; [2007]
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Ageing; Apoptosis; Biological gabarge; Hormesis; Lipofuscin; Lysosome; VETERINARY MEDICINE Pathology; VETERINÄRMEDICIN Patologi;

    Abstract : The lysosomal compartment is a major site for intracellular degradation. Lysosomal degradation of the cell’s own constituents, so-called autophagy, not only provides a cell with nutrients, but also removes damaged and potentially dangerous endogenous structures, thus securing intracellular homeostasis. READ MORE