Search for dissertations about: "thesis on PROTEASE"

Showing result 16 - 20 of 375 swedish dissertations containing the words thesis on PROTEASE.

  2. 16. On the Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : From Tripeptides to Achiral Compounds

    Author : Pernilla Örtqvist; Anja Sandström; Mats Larhed; Anders Hallberg; Morten Grøtli; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis C virus; NS3 protease inhibitor; structure-activity relationship; resistance; 2 1H -pyrazinone; phenylglycine; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Infection by the hepatitis C virus (HCV) leads to inflammation of the liver, i.e. hepatitis. The acute infection often progresses to a chronic phase during which the liver function is gradually impaired. READ MORE

  4. 17. Kallikrein-related peptidases in human epidermis : studies on activity, regulation, and function

    Author : Kristina Stefansson; Torbjörn Egelrud; Maria Brattsand; Mona Ståhle; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; desquamation; epidermis; stratum corneum; kallikrein-related peptidase; KLK; serine protease inhibitors; Dermatology and venerology; Dermatologi och venerologi;

    Abstract : Introduction. The outermost layer of the epidermis, the stratum corneum (SC), plays a fundamental role in our defense against microorganisms, chemicals, and dehydration. The SC is composed of tightly packed keratinized skin cells, corneocytes. For a functioning skin it is essential that corneocytes are constantly shed (desquamated). READ MORE

  5. 18. Identification of protease inhibitors against Flaviviruses and Coronaviruses

    Author : Dario Akaberi; Åke Lundkvist; Johan Lennerstrand; Josef D. Järhult; Ujjwal Neogi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antiviral research; protease inhibitors; flaviviruses; coronaviruses; ZIKV; TBEV; SARS-CoV-2;

    Abstract : Vector-borne flaviviruses and coronaviruses of zoonotic origins are important human pathogens and represent a serious threat to public health worldwide. Flaviviruses can be found on all continents, apart from Antarctica, where they are transmitted by arthropod vectors causing millions of infections every year. READ MORE

  6. 19. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Incorporating a P2 Cyclopentane-Derived Scaffold

    Author : Marcus Bäck; Anja Sandström; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HCV; NS3 protease; Proline mimic; Cyclopentane-derived scaffold; Linear inhibitors; Macrocyclic inhibitors; Organic synthesis; Organisk syntes;

    Abstract : This thesis describes the design, synthesis and structure-activity relationships analysis of potential inhibitors targeting the hepatitis C virus (HCV) NS3 protease. Also discussed is the disease caused by HCV infection and the class of enzymes known as proteases. READ MORE

  7. 20. Functional and structural studies of the Presequence protease, PreP

    Author : Hans G Bäckman; Elzbieta Glaser; Per Gardeström; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Presequence Protease; PreP; AtPreP; hPreP; Biochemistry; biokemi;

    Abstract : AtPreP (Arabidopsis thaliana Presequence Protease) is a zink metallooligopeptidase that is dually targeted to both mitochondria and chloroplasts. In these organelles it functions as a peptidasome that degrades the N-terminal targeting peptides that are cleaved off from the mature protein after protein import, as well as other unstructured peptides. READ MORE