Search for dissertations about: "thesis on anti-diabetic"

Showing result 1 - 5 of 32 swedish dissertations containing the words thesis on anti-diabetic.

2. 1. On anti-diabetic agents and the vasculature

   Author : Eva Linnéa Eriksson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Diabetes is rapidly increasing worldwide, and the number of patients suffering from diabetes is projected to rise with 50 % over the next 25 years, then affecting almost 600 million adults. Type 2 diabetes comprises 90-95 % of all people with diabetes, and they constitute a patient group that carries a high burden of cardiovascular disease. READ MORE

4. 2. Safety and Efficacy Modelling in Anti-Diabetic Drug Development

   Author : Bengt Hamrén; Mats O Karlsson; Eric Snoeck; Uppsala universitet; []
   Keywords : Pharmaceutical biosciences; pharmacokinetic; pharmacodynamic; mechanism-based; modelling; type 2 diabetes mellitus; tesaglitazar; PPAR; drug development; NONMEM; Farmaceutisk biovetenskap;

   Abstract : A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population. Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. READ MORE

5. 3. Assessment of anti-diabetic effect of Vietnamese herbal drugs

   Author : Nguyen Khanh Hoa; Karolinska Institutet; Karolinska Institutet; []
   Keywords : G-protein; type 2 diabetes; phanoside; antidiabetic plant; hypoglycemic agent; insulin secretion; pancreatic islets; Gynostemma pentaphyllum; Anemarrhena asphodeloides; Angiopteris evecta;

   Abstract : The prevalence of type 2 diabetes mellitus is increasing in Vietnam as well as in other developing countries (China, Indian subcontinent, and Africa). Searching for hypoglycemic agents with origin from domestic herbals was considered as a useful way to find novel therapy of the disease. After treatment i.p. READ MORE

6. 4. Anti-diabetic effect of gynostemma pentaphyllum tea in type 2 diabetes

   Author : Thi Thanh Huyen Vu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : herbal medicine;

   Abstract : Type 2 diabetes mellitus (T2D) is a major non-communicable disease and an important health burden worldwide, especially in the developing countries including Vietnam. Gynostemma pentaphyllum has been widely used in Vietnam as a herbal medicine for the prevention and treatment of T2D but the mechanism related to its effects is unknown. READ MORE

7. 5. Anti-diabetic and anti-inflammatory effects of medicinal plants in a type 2 diabetic animal model

   Author : Ezarul Faradianna Lokman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Type 2 diabetes;

   Abstract : Medicinal plants have been suggested since ancient times to be a good source of drugs for treating diabetes. The aims of this thesis were to identify the anti-diabetic effects and to understand further the mechanisms involved for two traditional plants, borapetol B (C1) isolated from Tinospora crispa, and Gynostemma pentaphyllum (GP), in diabetic rats. READ MORE