Search for dissertations about: "thesis on fibrinolytic enzyme"

Showing result 1 - 5 of 11 swedish dissertations containing the words thesis on fibrinolytic enzyme.

2. 1. Studies on fibrin gel structure

   Author : Kamaran T Fatah; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Fibrinogen; fibrin gel structure; plasma; thrombin; fibrinolysis; fibrin gel; zinc ion; plasminogen; crosslinking; acetylsalicylic acid; atherosclerosis; coronary heart disease;

   Abstract : Fibrin gel formation is the final result of interaction between multiple plasma proteins; as a result of activation, fibrinogen is converted to fibrin and crosslinking of fibrin occurs by activated factor XIII, which stabilises the formed clot. Fibrin gel networks were studied in purified fibrinogen systems and in plasma samples from patients with cardiovascular complications and healthy individuals, using light-scattering, turbidity, liquid permeation and confocal 3D microscopy techniques. READ MORE

4. 2. Local regulation of the endogenous fibrinolytic system in man

   Author : Thordis Hrafnkelsdottir; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tissue-type plasminogen activator; plasminogen activator inhibitor type-1; endothelium; extracellular nucleotides; hypertension; chronic renal failure;

   Abstract : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (tPA). The endothelium synthesises and stores tPA and regulated release of the enzyme is an important mechanism for removal of fibrin from blood vessels. Plasminogen activator inhibitor type-1 (PAI-1) is the main inhibitor of tPA. READ MORE

5. 3. Antiplasmin the main plasmin inhibitor in blood plasma : studies on structure-function relationships

   Author : Haiyao Wang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Antiplasmin; lysine-binding-site; inactivation;

   Abstract : Antiplasmin is an important regulator of the fibrinolytic system. It inactivates plasmin very rapidly. The reaction between plasmin and antiplasmin occurs in several steps: first a lysine-binding site in plasmin interacts with a complementary site in antiplasmin. READ MORE

6. 4. On the Regulation of the Serine Protease t-PA and its Inhibitor PAI-1 in the Brain

   Author : Karin Hultman; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; astrocytes; blood-brain barrier; plasminogen activator inhibitor type-1; polymorphisms; protease nexin-1; tissue-type plasminogen activator; transcriptional regulation;

   Abstract : The serine protease tissue-type plasminogen activator (t-PA) is the main fibrinolytic enzyme in the vascular system, and thus plays a critical role in the dissolution of thrombi. In recent years, researchers have focused on its role within the brain, where t-PA has been shown to participate in a number of physiological and pathophysiological processes, including various aspects of synaptic plasticity and neurodegeneration. READ MORE

7. 5. Epigenetic regulation of gene expression in the vascular endothelium

   Author : Mia Magnusson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epigenetics; histone acetylation; DNA methylation; t-PA; PLAT; HUVECs; valproic acid; gene expression; enhancers;

   Abstract : Epigenetic mechanisms, such as DNA methylation and histone modifications, constitute one way for a cell or an organism to respond to changes in the surrounding environment. While histone modifications are recognized to be quite dynamic, DNA methylation has been considered a more stable, or long-term, modification. READ MORE