Search for dissertations about: "thesis on nasal drug delivery"

Found 5 swedish dissertations containing the words thesis on nasal drug delivery.

  1. 1. Nasal Drug Delivery In Vitro Studies on Factors Influencing Permeability and Implications on Absorption

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Cecilia Wadell; Uppsala universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate implications for drug absorption via the nasal route. READ MORE

  2. 2. Studies on a Novel Powder Formulation for Nasal Drug Delivery

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Nelly Fransén; Uppsala universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nasal drug delivery; nasal powder spray; interactive mixture; mucoadhesion; sodium starch glycolate; superdisintegrant; bioavailability; clinical trial; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci;

    Abstract : Nasal administration has potential for the treatment of indications requiring a fast onset of effect or for drugs with low oral bioavailability. Liquid nasal sprays are relatively common, but can be associated with suboptimal absorption from the nasal cavity; this thesis shows that nasal absorption can be significantly enhanced with a dry powder formulation. READ MORE

  3. 3. The Horizontal Ussing Chamber Method in Studies of Nasal Drug Delivery Method Development and Applications Using Different Formulations

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Karin Östh; Uppsala universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The results from this thesis leads to the following conclusions; HUM is a useful tool that fills a gap in the in vitro methods previously available to study nasal drug delivery. Using HUM, the pig respiratory nasal mucosa can obtain acceptable viability and retain it longer than the period of time needed for a transport experiment. READ MORE

  4. 4. Controlled Release Gel Formulations for Mucosal Drug Delivery

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mattias Paulsson; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Galenisk farmaci; Pharmaceutics;

    Abstract : Drug delivery to nasal or ocular mucosa for either local or systemic action faces many obstacles – these routes are protected by effective mechanisms. Gel formulations with suitable rheological and mucoadhesive properties increase the contact time at the site of absorption. READ MORE

  5. 5. Humming, nitric oxide and paranasal sinus ventilation

    University dissertation from Stockholm : Karolinska Institutet, Department of Physiology and Pharmacology

    Author : Mauro Maniscalco; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The paranasal sinuses are air-filled bony cavities surrounding the nose. They communicate with the nose via the sinus ostia through which fluid and gases pass in both directions. A proper ventilation is crucial for sinus integrity and blockage of the ostia is a major risk factor for development of sinusitis. READ MORE