Search for dissertations about: "thesis on pulmonary medicine"

Showing result 11 - 15 of 290 swedish dissertations containing the words thesis on pulmonary medicine.

  2. 11. Pulmonary Drug Absorption : In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties

    Author : Ann Tronde; Gerrit Borchard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; lung; pulmonary; drug delivery; inhalation; drug transport; pharmacokinetics; absorption; bioavailability; drug metabolism; preclinical; rat; in vivo; isolated and perfused lung; Caco-2; nebulization catheter; aerosol; physicochemical; peptide; efflux; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. READ MORE

  4. 12. Perioperative complications in obese patients : A thesis on risk reducing strategies

    Author : Fredrik Ander; Lars Berggren; Rebecca Ahlstrand; Alex de Leon; Johan Raeder; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intubation time; videolaryngoscopy; obesity; esophagogastric junction; remifentanil; esmolol; high-resolution manometry; pulmonary aspiration; postoperative pain; postoperative opioid-sparing;

    Abstract : Aspiration of gastric content and delayed or failed intubation are the leading causes of anesthesia-related mortality and morbidity. In the recovery period, airway obstruction with subsequent hypoxia is a relatively common cause of morbidity, and is highly associated to the amount of opioids administered, especially in obese patients. READ MORE

  5. 13. Effects of anasthesia on esophageal sphincters

    Author : Rebecca Ahlstrand; Magnus Wattvil; Johan Ullman; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lower esophageal shincter; Upper esophageal sphincter; Barrier pressure; Manometry; Propofol; Remifentanil; Alfentanil; Rocuronium; Cricoid pressure; MEDICINE; MEDICIN; Surgery; Kirurgi; Anaesthetics; Anestesiologi; Anaesthesiology; Anestesiologi;

    Abstract : The esophageal sphincters constitute the anatomical protection against pulmonary aspiration. The aim of this thesis was to study the esophageal sphincters and how they are affected by different components of emergency anesthesia using high-resolution solid-state manometry.The effect of propofol (0. READ MORE

  6. 14. Regional Lung Mechanics and Influence of an Active Diaphragm in Experimental Lung Injury

    Author : Mariangela Pellegrini; Anders Sune Larsson; Göran Hedenstierna; Michael Quintel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute respiratory distress syndrome; artificial respiration; diaphragm; pulmonary atelectasis; lung imaging; respiratory system; animal model; Fysiologi; Physiology; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Abstract : Despite being an essential life-support strategy in severe respiratory failure, mechanical ventilation can, if not optimally set and monitored, lead to injury of the lung parenchyma and diaphragm. These conditions are called ventilator-induced lung injury and ventilator-induced diaphragmatic dysfunction (VIDD), respectively. READ MORE

  7. 15. Attenuation correction in pulmonary and myocardial single photon emission computed tomography

    Author : Helén Almquist; Lund Klinisk fysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk fysiologi; tomography; medical instrumentation; radiology; Clinical physics; downscatter; myocardial perfustion; ventilation-perfusion ratio; radiologi; pulmonary density; pulmonary perfusion; attenuation correction; SPECT; transmission measurement; tomografi; medicinsk instrumentering;

    Abstract : The objective was to develop and validate methods for single photon emission computed tomography, SPECT, allowing quantitative physiological and diagnostic studies of lung and heart. A method for correction of variable attenuation in SPECT, based on transmission measurements before administration of an isotope to the subject, was developed and evaluated. READ MORE