Search for dissertations about: "thesis on radioligand binding assay"

Showing result 1 - 5 of 8 swedish dissertations containing the words thesis on radioligand binding assay.

2. 1. Amino acid transport and receptor binding properties in neuropsychiatric disorders using the fibroblast cell model

   Author : Jessica Johansson; Nikolaos Venizelos; Lars Oreland; Örebro universitet; []
   Keywords : Fibroblasts; Bipolar disorder; ADHD; Tyrosine; Tryptophan; Alanine; Transport; mAChRs; Biomedicin; Biomedicine;

   Abstract : Altered transport of the catecholamines and serotonin precursor amino acids tyrosine and tryptophan, might be one explanation for the dysfunctional neurotransmission implicated in the pathophysiology of bipolar disorder and Attention Deficit/Hyperactivity Disorder (ADHD). In previous studies, an altered amino acid transport has been found in schizophrenia and autism, when using the fibroblast cell model. READ MORE

4. 2. The role of the serotonergic system and the effects of antidepressants during brain development examined using in vivo PET imaging and in vitro receptor binding

   Author : Stal Saurav Shrestha; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Serotonin (5-HT) and the serotonergic system, which includes the serotonin transporter (SERT) and the two G protein-coupled 5-HT1A and 5-HT1B receptors, are implicated in the pathophysiology and treatment of several neuropsychiatric disorders including major depressive disorder (MDD) and anxiety. Two classes of antidepressants—selective serotonin reuptake inhibitors (SSRIs), which block SERT, and tricyclic antidepressants (TCAs), which block several monoamine transporters—alter 5-HT levels and modulate the serotonergic system. READ MORE

5. 3. Harnessing the molecular Trojan horse : Evaluating properties of preclinical Aβ immunoPET radioligands for optimized brain delivery via the transferrin receptor

   Author : Gillian Bonvicini; Stina Syvänen; Johanna Fälting; Dag Sehlin; Ken Honek; Sahar Roshanbin; Joy Zuchero; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transferrin receptor TfR ; bispecific antibody; brain delivery; positron emission tomography PET ; Alzheimer’s disease; pharmacokinetics; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Abstract : With high specificity and selectivity to targets, antibodies are prime candidates for positron emission tomography (PET) radioligands. They do not passively cross the blood-brain barrier which has hindered their development for imaging intrabrain targets, like amyloid-β (Aβ) in Alzheimer’s disease. READ MORE

6. 4. Adenosine A2A receptors : characterization, localization, G protein coupling and interactions with dopamine D2 receptors

   Author : Björn Kull; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Adenosine receptors; receptor-receptor interactions; G proteins; species differences;

   Abstract : Adenosine not only has a role in cellular energy metabolism but is recognized as an intercellular messenger with an important function in physiology and pathophysiology. It exerts its effects via a family of G protein coupled receptors of which four members have been cloned from several species: A, A2A, A2B and A3. READ MORE

7. 5. The Perfect Storm? Gluten and type 1 diabetes

   Author : Emma Adlercreutz; Celiaki och diabetes; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NKG2D; Celiac disease autoimmunity; Gluten; Type 1 diabetes; Perinatal risk;

   Abstract : Aim: The general objective of the present research was to study the association between type 1 diabetes and celiac disease, and the effects of dietary gluten on the risk of developing type 1 diabetes. More specific aims were as follows: to estimate the prevalence of celiac-disease-associated autoantibodies in children with type 1 diabetes; to study the connection between non-HLA genetic risk markers and autoantibodies associated with type 1 diabetes and celiac disease during the first year after diagnosis of type 1 diabetes; to investigate the effect of gluten on the risk of developing type 1 diabetes; to evaluate the impact of perinatal factors on the risk of developing both type 1 diabetes and celiac disease. READ MORE