Search for dissertations about: "thesis on splenomegaly"

Showing result 1 - 5 of 15 swedish dissertations containing the words thesis on splenomegaly.

  2. 1. Genetic diversity of Plasmodium falciparum infections : influence on protective malaria immunity

    Author : Sándor Bereczky; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malaria; Plasmodium falciparum; genetic diversity; msp2; IgE; subsequent risk; asymptomatic; DNA extraction; ethnic group; spleen enlargement; hemoglobin;

    Abstract : Detailed knowledge of the interaction between the human host and the antigenic and genetic diversity of Plasmodium falciparum infections is a prerequisite for understanding the mechanisms underlying acquisition of immunity to malaria. This thesis assessed the diversity of P. READ MORE

  4. 2. Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer

    Author : Annika Wahlström; Göteborgs universitet; []
    Keywords : RCE1; ICMT; K-RAS; CAAX proteins; MPD; lung cancer;

    Abstract : CAAX proteins, such as the RAS and RHO proteins, are recognized by a specific CAAX motif at the carboxyl terminus, which undergoes posttranslational modifications. First, a lipid group is attached to the cysteine (the “C”) of the CAAX motif by farnesyltransferase (FTase) or geranylgeranyltransferase-I (GGTase-I); second, the –AAX are removed by RAS converting enzyme 1 (RCE1); and third, the cysteine is methylated by isoprenylcysteine carboxyl methyltransferase (ICMT). READ MORE

  5. 3. Immunity to Salmonella infection

    Author : Cecilia Johansson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; cytokines; antigen presentation; liver; dendritic cells; Salmonella; gram negative bacteria;

    Abstract : The immune system has several strategies to combat infections. The present study investigates various aspects of the interaction between Gram negative bacteria, particularly Salmonella, and antigen presenting cells (APC). Salmonella is an intracellular bacterium infecting mice and man. READ MORE

  6. 4. Mechanistic study of antiangiogenic agents in cancer therapy

    Author : Yin Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tumor growth and metastasis are dependent on angiogenesis that constantly alters the tumor microenvironment. Based on the antiangiogenic principle proposed more than 40 years ago by Dr. READ MORE

  7. 5. Population-Based Long-Term Follow-up of Patients with Myeloproliferative Neoplasms, complications and prognosis

    Author : Khadija Abdulkarim; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; essential thrombocythemia; polycythemia vera; myelofibrosis;

    Abstract : ABSTRACT Philadelphia chromosome negative myeloproliferative neoplasms (Ph-MPNs) are rare clonal hematological malignancies, mainly including polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF). Patients with these diseases run a high risk of vascular complications and may transform to acute myeloid leukemia (AML). READ MORE